Kevin Patrick Becker, MD
Assistant Professor of Neurology
Research Interests
Brain Neoplasms; Glioblastoma; Immunotherapy; Medical Oncology; Neurology; Nanoparticles
Research Organizations
Research Summary
My current research focus is bringing novel treatments and therapeutics to clinical trial for patients with primary brain tumors. Areas currently being developed include immunotherapeutics and novel drug delivery (use of nano-particles) to treat glioblastoma.
Specialized Terms: Primary brain tumors; Immunotherapeutics; Novel drug delivery; Nano-particles in the treatment of glioblastoma
Extensive Research Description
Bibliography:
Jenco, J.M., Becker, K.P. and Morris, A.J. (1997).
Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role
of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+. Biochem.
J. 327:431- 437<_o3a_p>
<_o3a_p>
Becker, K.P., Ullian, M., and Halushka, P.V. (1998). Cloning and Characterization of an Endogenous COS-7 Cell Thromboxane A2 Receptor. Biochimica et. Biophysica Acta. 1403:109-114<_o3a_p>
<_o3a_p>
Becker, K.P., Garnovskaya, M., Gettys, T., and Halushka, P.V. (1999). Coupling of thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and signaling. Biochimica et Biophysica Acta. 1450: 288-296<_o3a_p>
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Feng, X., Becker, K.P., Striblling, D.S., Peters, K.G. and Hannun, Y.A. (2000). Regulation of Receptor-Mediated Protein Kinase C Membrane Trafficking by Autophosphorylation. J.Biol. Chem. 272: 17024-17034<_o3a_p>
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Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262<_o3a_p>
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Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547<_o3a_p>
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Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191<_o3a_p>
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Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754 <_o3a_p>
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Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256. <_o3a_p>
<_o3a_p>
Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612<_o3a_p>
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Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31. <_o3a_p>
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Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)<_o3a_p>
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2. Case Reports, Technical Notes, Lectures:
Becker, K.P., Huttner, A., and Baehring, J.M. Leptomeningeal Dissemination of Low Grade Brain Tumors: A Report on Four Cases and Review of the Medical Literature (in preparation)<_o3a_p>
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Becker, K.P., Lacy, J., Cooper, D., and Baehring, J.M. Autologous Stem Cell Transplant in Patient with Relapsed Central Nervous System Lymphoma: A Case Series and Review of the Literature (in preparation)<_o3a_p>
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3. Reviews, Chapters, Books
Becker, K.P., and Hannun, Y.A: The Multifaceted Role of Diacylglycerol, in Bioactive Lipids, Vol17, A. Nicolaou and G. Kokotos (eds).England, PJ Barnes and Associates, 2004, pp 37-61<_o3a_p>
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Becker, K.P., Hannun, Y.A. (2005) Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cellular and Molecular Life Sciences 62: 1448-61. <_o3a_p>
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4. Papers in Press
Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).<_o3a_p>
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Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).<_o3a_p>
Selected Publications
- Spinal Cord Compression. Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Increased Intracranial Pressure Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Diffusion-Weighted Imaging in Patients Treated with Bevacizumab Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)
-
Dynamic sequestration of the recycling compartment by classical Protein Kinase C
Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31.
-
Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway
Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612
-
Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment
Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.
-
cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes
Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754
-
Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides
Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191
-
Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability
Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547
-
PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA)
Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262
-
Regulation of Receptor-Mediated Protein Kinase C Membrane Trafficking by Autophosphorylation
Feng, X., Becker, K.P., Striblling, D.S., Peters, K.G. and Hannun, Y.A. (2000). Regulation of Receptor-Mediated Protein Kinase C Membrane Trafficking by Autophosphorylation. J.Biol. Chem. 272: 17024-17034
-
Coupling of thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and signaling
Becker, K.P., Garnovskaya, M., Gettys, T., and Halushka, P.V. (1999). Coupling of thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and signaling. Biochimica et Biophysica Acta. 1450: 288-296
-
Cloning and Characterization of an Endogenous COS-7 Cell Thromboxane A2 Receptor
Becker, K.P., Ullian, M., and Halushka, P.V. (1998). Cloning and Characterization of an Endogenous COS-7 Cell Thromboxane A2 Receptor. Biochimica et. Biophysica Acta. 1403:109-114
-
Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+
Jenco, J.M., Becker, K.P. and Morris, A.J. (1997). Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+. Biochem. J. 327:431- 437
Full List of PubMed Publications
- Waltz TB, Fivenson EM, Morevati M, Li C, Becker KG, Bohr VA, Fang EF: Sarcopenia, aging and prospective interventional strategies. Curr Med Chem. 2017 Jul 31; 2017 Jul 31. PMID: 28762310
- Barbiero FJ, Baehring JM, Fulbright RK, Becker KP: MRI findings in Collet-Sicard syndrome. Neurology. 2017 Feb 21. PMID: 28220011
- Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Kelly JR, Baehring JM, Becker KP, Yu JB, Bindra RS, Roberts KB: Adjuvant chemotherapy and overall survival in adult medulloblastoma. Neuro Oncol. 2017 Feb 1. PMID: 27540083
- Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016 Apr 14; 2016 Apr 4. PMID: 27042933
- Blondin NA, Becker KP: Anaplastic gliomas: radiation, chemotherapy, or both? Hematol Oncol Clin North Am. 2012 Aug; 2012 May 11. PMID: 22794285
- Guez-Barber D, Fanous S, Harvey BK, Zhang Y, Lehrmann E, Becker KG, Picciotto MR, Hope BT: FACS purification of immunolabeled cell types from adult rat brain. J Neurosci Methods. 2012 Jan 15; 2011 Sep 3. PMID: 21911005
- Becker KP, Yu J: Status quo--standard-of-care medical and radiation therapy for glioblastoma. Cancer J. 2012 Jan-Feb. PMID: 22290252
