Melinda Liggett Irwin, PhD, MPH

Research Interests

Breast Neoplasms; Neoplasms by Histologic Type; Obesity; Ovarian Neoplasms; Weight Loss; Exercise

Public Health Interests

Cancer; Cancer Epidemiology

Research Organizations

School of Public Health: Chronic Disease Epidemiology

Faculty Research

Obesity Research Working Group

Yale Cancer Center: Cancer Prevention and Control

Office of Cooperative Research

Research Summary

Professor Irwin's primary research interests are in the areas of energy balance and cancer prevention and prognosis. She is trained in cancer epidemiology, exercise physiology, and clinical trials. Specifically, Professor Irwin's research involves examining the effect of exercise and weight loss on cancer biomarkers, treatment side effects and quality of life.

Speciailzed Terms: Energy balance; Cancer prevention and prognosis

Selected Publications

• Influence of pre- and post-diagnosis physical activity on mortality in breast cancer survivors: The Health Eating Activity and Lifestyle (HEAL) Study.

  Irwin ML, Smith A, McTiernan A, Cronin K, Ballard-Barbash R, Baumgartner R, Gilliland F, Bernstein L. Influence of pre- and post-diagnosis physical activity on mortality in breast cancer survivors: The Health Eating Activity and Lifestyle (HEAL) Study. Journal of Clinical Oncology, 2008 Aug 2026(24):3958-64.

• Randomized controlled exercise trial on insulin and IGFs in breast cancer survivors: The Yale Exercise and Survivorship Study.

  Irwin ML, Varma K, Alvarez-Reeves, et al. Randomized controlled exercise trial on insulin and IGFs in breast cancer survivors: The Yale Exercise and Survivorship Study. Cancer Epidemiol Biomarker Prev. 2009 18(1): 306-13.

• Exercise improves body fat, lean mass, and bone mass in breast cancer survivors.

  Irwin ML, Alvarez-Reeves M, Cadmus L, et al. Randomized controlled exercise trial on body fat, lean mass, and bone mineral density in breast cancer survivors: The Yale Exercise and Survivorship Study. Obesity. 2009. 17(8):1534-41.

• Impact of nutrition and exercise on cancer survival.

  Irwin ML, Mayne ST. Impact of nutrition and physical activity on cancer survival. The Cancer Journal: The Journal of Principles and Practices of Oncology, 2008 14(6): 435-41.

• Relationship of obesity and physical activity with c-peptide, leptin, and insulin-like growth factors in breast cancer survivors.

  Irwin ML, McTiernan A, Bernstein L, et al. Relationship of obesity and physical activity with c-peptide, leptin, and insulin-like growth factors in breast cancer survivors. Cancer Epidemiology Biomarkers Prevention. 2005 14(12): 2881-8

• Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors.

  Irwin, M.L., McTiernan, A., Baumgartner, R.N., Baumgartner, K.B., Bernstein, L., Gilliland, F.D., and Ballard-Barbash, R. Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors. Journal of Clinical Oncology 23(4): 774-782, 2005.

• Physical activity levels among breast cancer survivors.

  Irwin, M.L., McTiernan, A., Bernstein, L., Gilliland, F.D., Baumgartner, R., Baumgartner, K., and Ballard-Barbash, R. Physical Activity Levels Among Breast Cancer Survivors. Medicine & Science in Sports & Exercise 36(9): 1484-1491, 2004.

• Physical Activity Levels Before and After a Diagnosis of Breast Carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) Study.

  Irwin, M.L., Crumley, D., McTiernan, A, Bernstein, L., Baumgartner, R., Gilliland, F.D., Kriska, A., and Ballard-Barbash, R. Physical Activity Levels Before and After a Diagnosis of Breast Carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) Study. Cancer 97(7): 1746-1757, 2003

• Physical activity and survival in women diagnosed with breast cancer: Results from the Women’s Health Initiative.

  Irwin ML, McTiernan A, Manson J, Thompson C, Sternfeld B, Stefanick M, Wactawski-Wende J, Craft L, Lane D, Martin L, Chlebowski R. Physical activity and survival in women diagnosed with breast cancer: Results from the Women’s Health Initiative. Cancer Prevention Research. 2011;4(4): 522-9.

• Fasting C-peptide levels and death due to all causes and breast cancer: The Health Eating Activity and Lifestyle (HEAL) Study.

  Irwin ML, Duggan C, Smith A, Ballard-Barbash R, Bernstein L, Baumgartner R, Baumgartner K, McTiernan A. Fasting C-peptide levels and death due to all causes and breast cancer: The Health Eating Activity and Lifestyle (HEAL) Study. Journal of Clinical Oncology, 2011; 29(1): 47-53.

• Effect of Exercise on Total and Intra-Abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial.

  Irwin, M.L., Yasui, Y., Ulrich, C.M., Bowen, D., Rudolph, R.E., Schwartz, R.S., Yukawa, M., Aiello, E., Potter, J.D., and McTiernan, A. Effect of Exercise on Total and Intra-Abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial. Journal of the American Medical Association 289(3): 323-330, 2003.

• Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: results from the Women's Health Initiative.

  Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: results from the Women's Health Initiative. Gynecol Oncol. 2014 Apr;133(1):4-10

• Irwin ML, Cartmel B, Gross C, et al. Randomized trial of exercise on aromatase inhibitor-associated arthralgias: The Hormones and Physical Exercise (HOPE) Study. J Clin Oncol. 2015 Apr 1;33(10):1104-11
• Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis.

  Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2015 Sep 30;107(12).

Full List of PubMed Publications

• Iyer NS, Cartmel B, Friedman L, Li F, Zhou Y, Ercolano E, Harrigan M, Gottlieb L, McCorkle R, Schwartz PE, Irwin ML: Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. Cancer. 2018 May 1; 2018 Feb 13. PMID: 29437202
• Adams BD, Arem H, Hubal MJ, Cartmel B, Li F, Harrigan M, Sanft T, Cheng CJ, Pusztai L, Irwin ML: Exercise and weight loss interventions and miRNA expression in women with breast cancer. Breast Cancer Res Treat. 2018 Mar 6; 2018 Mar 6. PMID: 29511965
• Demark-Wahnefried W, Schmitz KH, Alfano CM, Bail JR, Goodwin PJ, Thomson CA, Bradley DW, Courneya KS, Befort CA, Denlinger CS, Ligibel JA, Dietz WH, Stolley MR, Irwin ML, Bamman MM, Apovian CM, Pinto BM, Wolin KY, Ballard RM, Dannenberg AJ, Eakin EG, Longjohn MM, Raffa SD, Adams-Campbell LL, Buzaglo JS, Nass SJ, Massetti GM, Balogh EP, Kraft ES, Parekh AK, Sanghavi DM, Morris GS, Basen-Engquist K: Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin. 2018 Jan; 2017 Nov 22. PMID: 29165798
• Huo X, Spatz ES, Ding Q, Horak P, Zheng X, Masters C, Zhang H, Irwin ML, Yan X, Guan W, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM, Jiang L: Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes. BMJ Open. 2017 Dec 21; 2017 Dec 21. PMID: 29273661
• Ligibel JA, Barry WT, Alfano C, Hershman DL, Irwin M, Neuhouser M, Thomson CA, Delahanty L, Frank E, Spears P, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hahn O, Hudis C, Winer EP, Wadden TA, Goodwin PJ: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design. NPJ Breast Cancer. 2017; 2017 Sep 21. PMID: 28948213
• Playdon MC, Ziegler RG, Sampson JN, Stolzenberg-Solomon R, Thompson HJ, Irwin ML, Mayne ST, Hoover RN, Moore SC: Nutritional metabolomics and breast cancer risk in a prospective study. Am J Clin Nutr. 2017 Aug; 2017 Jun 28. PMID: 28659298
• Irwin ML, Cartmel B, Harrigan M, Li F, Sanft T, Shockro L, O'Connor K, Campbell N, Tolaney SM, Mayer EL, Yung R, Freedman RA, Partridge AH, Ligibel JA: Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors. Cancer. 2017 Apr 1; 2016 Nov 28. PMID: 27893938
• Minges KE, Whittemore R, Weinzimer SA, Irwin ML, Redeker NS, Grey M: Correlates of overweight and obesity in 5529 adolescents with type 1 diabetes: The T1D Exchange Clinic Registry. Diabetes Res Clin Pract. 2017 Apr; 2017 Feb 4. PMID: 28214669
• Arem H, Pfeiffer RM, Moore SC, Irwin ML, LaMonte MJ, Sarto GE, Nassir R, Luo J, Chlebowski RT, Brinton LA, Matthews CE: Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. PLoS One. 2017; 2017 Feb 2. PMID: 28152055
• Playdon MC, Moore SC, Derkach A, Reedy J, Subar AF, Sampson JN, Albanes D, Gu F, Kontto J, Lassale C, Liao LM, Männistö S, Mondul AM, Weinstein SJ, Irwin ML, Mayne ST, Stolzenberg-Solomon R: Identifying biomarkers of dietary patterns by using metabolomics. Am J Clin Nutr. 2017 Feb; 2016 Dec 28. PMID: 28031192
• Thomas GA, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, Ercolano E, Gross CP, Hershman D, Ligibel J, Schmitz K, Li FY, Sanft T, Irwin ML: The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors. Obesity (Silver Spring). 2017 Feb; 2016 Dec 27. PMID: 28026901
• Buffart LM, Kalter J, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Lucia A, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J: Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs. Cancer Treat Rev. 2017 Jan; 2016 Dec 5. PMID: 28006694
• Wong CK, Horn-Ross PL, Gee GC, Shariff-Marco S, Quach T, Allen L, Bautista R, La Chica PQ, Tseng W, Chang P, Clarke CA, Yang J, Le GM, Canchola A, Irwin ML, Lee SS, Gomez SL: Strategies for recruiting representative samples of Asian Americans for a population-based case-control study. J Epidemiol Community Health. 2016 Oct; 2016 Apr 6. PMID: 27053683
• Playdon MC, Sampson JN, Cross AJ, Sinha R, Guertin KA, Moy KA, Rothman N, Irwin ML, Mayne ST, Stolzenberg-Solomon R, Moore SC: Comparing metabolite profiles of habitual diet in serum and urine. Am J Clin Nutr. 2016 Sep; 2016 Aug 10. PMID: 27510537
• Anderson C, Harrigan M, George SM, Ferrucci LM, Sanft T, Irwin ML, Cartmel B: Changes in diet quality in a randomized weight loss trial in breast cancer survivors: the lifestyle, exercise, and nutrition (LEAN) study. NPJ Breast Cancer. 2016; 2016 Aug 24. PMID: 28721384
• Arem H, Sorkin M, Cartmel B, Fiellin M, Capozza S, Harrigan M, Ercolano E, Zhou Y, Sanft T, Gross C, Schmitz K, Neogi T, Hershman D, Ligibel J, Irwin ML: Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study. J Cancer Surviv. 2016 Aug; 2016 Jan 19. PMID: 26782031
• Zhou Y, Irwin ML, Ferrucci LM, McCorkle R, Ercolano EA, Li F, Stein K, Cartmel B: Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors - I. Gynecol Oncol. 2016 Jun; 2016 Apr 19. PMID: 27072805
• Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML: Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. J Clin Oncol. 2016 Mar 1; 2015 Nov 23. PMID: 26598750
• Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML: Response. J Natl Cancer Inst. 2016 Apr; 2016 Mar 1. PMID: 26933009
• Minges KE, Chao AM, Irwin ML, Owen N, Park C, Whittemore R, Salmon J: Classroom Standing Desks and Sedentary Behavior: A Systematic Review. Pediatrics. 2016 Feb; 2016 Jan 22. PMID: 26801914
• Ligibel JA, Alfano CM, Hershman D, Ballard RM, Bruinooge SS, Courneya KS, Daniels EC, Demark-Wahnefried W, Frank ES, Goodwin PJ, Irwin ML, Levit LA, McCaskill-Stevens W, Minasian LM, O'Rourke MA, Pierce JP, Stein KD, Thomson CA, Hudis CA: Recommendations for Obesity Clinical Trials in Cancer Survivors: American Society of Clinical Oncology Statement. J Clin Oncol. 2015 Nov 20; 2015 Aug 31. PMID: 26324364
• Wang Z, Risch H, Lu L, Irwin ML, Mayne S, Schwartz P, Rutherford T, De Vivo I, Yu H: Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk. Sci Rep. 2015 Oct 26; 2015 Oct 26. PMID: 26498156
• Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML: Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2015 Dec; 2015 Sep 30. PMID: 26424778
• Irwin ML, Cartmel B, Gross CP, Ercolano E, Li F, Yao X, Fiellin M, Capozza S, Rothbard M, Zhou Y, Harrigan M, Sanft T, Schmitz K, Neogi T, Hershman D, Ligibel J: Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors. J Clin Oncol. 2015 Apr 1; 2014 Dec 1. PMID: 25452437
• Bulloch KJ, Irwin ML, Chagpar AB, Pusztai L, Killelea BK, Horowitz NR, Hofstatter EW, Abu-Khalaf MM, DiGiovanna M, Chung GG, Sanft TB: Systematic approach to providing breast cancer survivors with survivorship care plans: a feasibility study. J Oncol Pract. 2015 Mar. PMID: 25784577
• Irwin ML, Fabian C, McTiernan A: Risk Reduction from Weight Management and Physical Activity Interventions. Adv Exp Med Biol. 2015. PMID: 26059937
• Thomson CA, E Crane T, Wertheim BC, Neuhouser ML, Li W, Snetselaar LG, Basen-Engquist KM, Zhou Y, Irwin ML: Diet quality and survival after ovarian cancer: results from the Women's Health Initiative. J Natl Cancer Inst. 2014 Nov; 2014 Oct 21. PMID: 25335480
• Irwin ML: Weight loss interventions and breast cancer survival: the time is now. J Clin Oncol. 2014 Jul 20; 2014 Jun 16. PMID: 24934785
• Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML: Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: results from the Women's Health Initiative. Gynecol Oncol. 2014 Apr. PMID: 24680584
• Arem H, Park Y, Pelser C, Barbash RB, Irwin ML, Hollenbeck A, Gierach GL, Brinton LA, Pfeiffer RM, Matthews CE: Response. J Natl Cancer Inst. 2014 Feb; 2014 Jan 4. PMID: 24389423
• Kwan K, Chlebowski RT, McTiernan A, Rodabough RJ, La Monte MJ, Martin LW, Bell C, Lane DS, Kaplan RC, Irwin ML: Walking speed, physical activity, and breast cancer in postmenopausal women. Eur J Cancer Prev. 2014 Jan. PMID: 23669264
• Hamilton JG, Birmingham WC, Tehranifar P, Irwin ML, Klein WM, Nebeling L, Chubak J: Transitioning to independence and maintaining research careers in a new funding climate: american society of preventive oncology junior members interest group report. Cancer Epidemiol Biomarkers Prev. 2013 Nov. PMID: 24190867
• Playdon M, Thomas G, Sanft T, Harrigan M, Ligibel J, Irwin M: Weight Loss Intervention for Breast Cancer Survivors: A Systematic Review. Curr Breast Cancer Rep. 2013 Sep; 2015 May 17. PMID: 26605003
• Arem H, Neuhouser ML, Irwin ML, Cartmel B, Lu L, Risch H, Mayne ST, Yu H: Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. Eur J Nutr. 2013 Apr; 2012 Aug 23. PMID: 22915050
• Jones SB, Thomas GA, Hesselsweet SD, Alvarez-Reeves M, Yu H, Irwin ML: Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study. Cancer Prev Res (Phila). 2013 Feb; 2012 Dec 4. PMID: 23213072
• Arem H, Chlebowski R, Stefanick ML, Anderson G, Wactawski-Wende J, Sims S, Gunter MJ, Irwin ML: Body mass index, physical activity, and survival after endometrial cancer diagnosis: results from the Women's Health Initiative. Gynecol Oncol. 2013 Feb; 2012 Nov 2. PMID: 23127972
• Thomas GA, Alvarez-Reeves M, Lu L, Yu H, Irwin ML: Effect of exercise on metabolic syndrome variables in breast cancer survivors. Int J Endocrinol. 2013; 2013 Nov 11. PMID: 24319454
• Zeng H, Irwin ML, Lu L, Risch H, Mayne S, Mu L, Deng Q, Scarampi L, Mitidieri M, Katsaros D, Yu H: Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1. Breast Cancer Res Treat. 2012 May; 2011 Aug 12. PMID: 21837478
• Lu L, Risch H, Irwin ML, Mayne ST, Cartmel B, Schwartz P, Rutherford T, Yu H: Long-term overweight and weight gain in early adulthood in association with risk of endometrial cancer. Int J Cancer. 2011 Sep 1; 2011 Apr 25. PMID: 21387312
• Lu L, Zhang C, Zhu G, Irwin M, Risch H, Menato G, Mitidieri M, Katsaros D, Yu H: Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome. Breast Cancer Res. 2011 Jun 6; 2011 Jun 6. PMID: 21645396
• Irwin ML, McTiernan A, Manson JE, Thomson CA, Sternfeld B, Stefanick ML, Wactawski-Wende J, Craft L, Lane D, Martin LW, Chlebowski R: Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative. Cancer Prev Res (Phila). 2011 Apr. PMID: 21464032
• Arem H, Irwin ML, Zhou Y, Lu L, Risch H, Yu H: Physical activity and endometrial cancer in a population-based case-control study. Cancer Causes Control. 2011 Feb; 2010 Nov 26. PMID: 21110224
• Zhou Y, Irwin ML, Risch HA: Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality. Gynecol Oncol. 2011 Feb; 2010 Nov 23. PMID: 21106231
• Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R: Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle study. J Clin Oncol. 2011 Jan 1; 2010 Nov 29. PMID: 21115859
• George SM, Neuhouser ML, Mayne ST, Irwin ML, Albanes D, Gail MH, Alfano CM, Bernstein L, McTiernan A, Reedy J, Smith AW, Ulrich CM, Ballard-Barbash R: Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2010 Sep; 2010 Aug 17. PMID: 20716617
• Latka RN, Alvarez-Reeves M, Cadmus L, Irwin ML: Adherence to a randomized controlled trial of aerobic exercise in breast cancer survivors: the Yale exercise and survivorship study. J Cancer Surviv. 2009 Sep; 2009 May 7. PMID: 19626443
• Dorsey K, Herrin J, Krumholz H, Irwin M: The utility of shorter epochs in direct motion monitoring. Res Q Exerc Sport. 2009 Sep. PMID: 19791632
• Irwin ML, Alvarez-Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, Chung GG, Jones B, Knobf MT, DiPietro L: Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity (Silver Spring). 2009 Aug; 2009 Feb 19. PMID: 19629060
• Irwin ML, Varma K, Alvarez-Reeves M, Cadmus L, Wiley A, Chung GG, Dipietro L, Mayne ST, Yu H: Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study. Cancer Epidemiol Biomarkers Prev. 2009 Jan. PMID: 19124513
• Irwin ML, Mayne ST: Impact of nutrition and exercise on cancer survival. Cancer J. 2008 Nov-Dec. PMID: 19060611
• Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L: Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study. J Clin Oncol. 2008 Aug 20. PMID: 18711185
• Irwin ML, Cadmus L, Alvarez-Reeves M, O'Neil M, Mierzejewski E, Latka R, Yu H, Dipietro L, Jones B, Knobf MT, Chung GG, Mayne ST: Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial: the Yale Exercise and Survivorship Study. Cancer. 2008 Jun 1. PMID: 18428192
• Irwin ML, Aiello EJ, McTiernan A, Bernstein L, Gilliland FD, Baumgartner RN, Baumgartner KB, Ballard-Barbash R: Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivors. J Clin Oncol. 2007 Mar 20; 2007 Jan 29. PMID: 17261853
• Irwin ML: Randomized controlled trials of physical activity and breast cancer prevention. Exerc Sport Sci Rev. 2006 Oct. PMID: 17031257
• Irwin ML, Aiello EJ, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R: Pre-diagnosis physical activity and mammographic density in breast cancer survivors. Breast Cancer Res Treat. 2006 Jan; 2005 Nov 30. PMID: 16319988
• Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R: Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2005 Dec. PMID: 16365005
• Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R: Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors. J Clin Oncol. 2005 Feb 1. PMID: 15681521
• Irwin ML, Tworoger SS, Yasui Y, Rajan B, McVarish L, LaCroix K, Ulrich CM, Bowen D, Schwartz RS, Potter JD, McTiernan A: Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women. Prev Med. 2004 Dec. PMID: 15539040
• Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R: Physical activity levels among breast cancer survivors. Med Sci Sports Exerc. 2004 Sep. PMID: 15354027
• Irwin ML, Ainsworth BE: Physical activity interventions following cancer diagnosis: methodologic challenges to delivery and assessment. Cancer Invest. 2004. PMID: 15069762
• Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard-Barbash R: Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer. 2003 Apr 1. PMID: 12655532
• Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A: Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA. 2003 Jan 15. PMID: 12525233
• Irwin ML, Ainsworth BE, Mayer-Davis EJ, Addy CL, Pate RR, Durstine JL: Physical activity and the metabolic syndrome in a tri-ethnic sample of women. Obes Res. 2002 Oct. PMID: 12376584

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