Oscar Rene Colegio, MD, PhD

Associate Professor of Dermatology, Transplant, and Pathology

Research Interests

Allergy and Immunology; Carcinoma, Squamous Cell; Dermatology; Melanoma; Epithelial-Mesenchymal Transition

Research Organizations

Dermatology: Colegio Lab | Dermatologic Surgery | Medical Dermatology


Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Summary

The focus of our lab is to characterize the role of immune cells called macrophages in tumor progression. The focus of these studies has been to identify pathways of tumorigenesis critical to a variety of murine tumor types including lung carcinoma, melanoma, colon carcinoma and cutaneous squamous cell carcinoma. In addition, we are performing parallel studies in identifying tumor-promoting pathways produced by infiltrating macrophages in human squamous cell carcinomas from immunosuppressed transplant recipients vs non-immunosuppressed patients.

Specialized Terms: Squamous cell carcinoma; Casal cell carcinoma; Melanoma; Tumor-associated macrophages; Immunology; Hypoxia; Epithelial-mesenchymal transitions; Solid organ transplantation

Extensive Research Description

  • The role of macrophages in progression of cutaneous squamous cell carcinomas

Selected Publications

Full List of PubMed Publications

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Contact Info

Oscar Rene Colegio, MD, PhD
Patient Care Locations
Yale Dermatology AssociatesDoctors Building
2 Church Street South, Ste 305

New Haven, CT 06519
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Yale Transplant Dermatology ClinicYale Physicians Building
800 Howard Avenue, Ste 4th Floor

New Haven, CT 06519
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Office Location
Laboratory OfficeHunter Building
15 York Street, Ste Suite 603b

New Haven, CT 06510
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Mailing Address
Dermatology333 Cedar Street, LMP 5040
PO Box 208059

New Haven, CT 06520-8059

Colegio Lab

Tumor-associated Macrophages in Human Melanoma

Metastatic melanoma with macrophages stained in brown and the inflammasome protein NLRC4 stained in fuschia.

Tumor-associated Macrophages Lung Carcinoma

Lung carcinoma, highlighting tumor-associated macrophages in yellow.