Steven H Kleinstein, PhD

Associate Professor of Pathology

Research Interests

Autoimmune Diseases; Computing Methodologies; Immune System Diseases; Information Science; Pattern Recognition, Automated; Virus Diseases; Computational Biology; Autoimmune Diseases of the Nervous System; Immune System Phenomena; Mathematical Concepts; Patient-Specific Modeling

Public Health Interests

Bioinformatics; Genomics; Infectious Disease; Influenza; Viruses; West Nile Virus

Research Organizations

Pathology: Informatics Program | Kleinstein Lab | Pathology Research

Immunobiology: HTI | Lymphocyte Development

Faculty Research

Liver Center

Medical Informatics, Yale Center for

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Summary

My research seeks to make fundamental contributions to immunology through the development and application of innovative computational methods. Somatic hypermutation (SHM) and B cell affinity maturation, the core of adaptive immunity, have been a long-term focus of my work, with a major emphasis on B cell immunoglobulin repertoire analysis. Over the past several years, my research has expanded to include methods for other high-throughput immune profiling data types, with several applications to influenza infection and vaccination responses. My lab has significant expertise in both bioinformatics and immunology and, although we do not directly perform wet-lab experiments, we work closely with experimental and clinical groups for the initial phases of hypothesis generation and experimental design.

Extensive Research Description

Information on projects is available from our lab website:

Selected Publications

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Contact Info

Steven H Kleinstein, PhD
Office Location
Department of Pathology300 George Street, Ste 505E
New Haven, CT 06511
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Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Kleinstein Lab Website