Apexigen and Yale Cancer Center Announce Clinical Collaboration to Evaluate APX005M, Cabiralizumab, and Opdivo (Nivolumab) in Patients whose Disease has Progressed on Anti-PD-1/PD-L1 Therapy
Apexigen, Inc., and Yale Cancer Center today announced a clinical trial collaboration to evaluate Apexigen's APX005M in combination with cabiralizumab and Opdivo in patients with advanced solid tumors. The Phase 1/2 clinical trial will evaluate the safety, tolerability, and preliminary activity of APX005M in combination with cabiralizumab and Opdivo in metastatic NSCLC, metastatic melanoma and RCC patients whose disease has progressed on prior anti-PD-1/PD-L1 therapy (www.clinicaltrials.gov: NCT03502330). In addition to providing funding, Bristol-Myers Squibb will supply Opdivo and cabiralizumab, an investigational antibody being developed in partnership with Five Prime Therapeutics.
Making milestones against non-small cell lung cancer
Hard to detect in its early stages and hard to treat as it advances, lung cancer is the leading cause of cancer mortality around the world, with an estimated 1.6 million deaths each year. New treatments, however, are bettering the odds for people with non-small cell lung cancer (NSCLC), which makes up about 85 percent of lung cancer cases.
Crystallizing discovery on a key target for cancer drugs
Many approved cancer therapies target a protein called epidermal growth factor receptor (EGFR) that regulates many crucial cellular processes and can speed the proliferation of tumor cells. Yale Cancer Center scientists now have made a fundamental discovery about EGFR signaling, reported in the journal Cell, that may open the potential for new types of cancer drugs.
Backed by Yale Cancer Center research, FDA approves new immunotherapy drug for stomach cancer
A drug whose clinical testing was led by Charles S. Fuchs, MD, MPH, director of Yale Cancer Center, has become the first immunotherapy treatment for advanced stomach cancer. The drug, pembrolizumab (Keytruda®), was approved by the U.S. Food and Drug Administration (FDA) for adult patients diagnosed with advanced stomach cancer showing PD-L1 positive tumors. Pembrolizumab works by increasing the ability of the body’s immune system to help detect and fight tumor cells. In 2017, an estimated 28,000 Americans will be diagnosed with stomach cancer.
New research alliance with pharma giant
Yale School of Medicine and the pharmaceutical company AstraZeneca (AZ) have embarked on a new collaboration, supported by AZ’s Oncology Global Medical Affairs group, that aims to speed translational and clinical research to develop lifesaving, next-generation therapies for lung and other cancers.Source: Medicine@Yale
A Cancer Conundrum: Too Many Drug Trials, Too Few Patients
With the arrival of two revolutionary treatment strategies, immunotherapy and personalized medicine, cancer researchers have found new hope — and a problem that is perhaps unprecedented in medical research. There are too many experimental cancer drugs in too many clinical trials, and not enough patients to test them on. Immunotherapy trials have proliferated so quickly that major medical centers are declining to furnish patients to them. The Yale Cancer Center participates in fewer than 10 percent of the immunotherapy trials it is asked to join. The problem is that many of the trials are uninteresting from a scientific view, said Dr. Roy Herbst, the center’s chief of medical oncology. The companies sponsoring these trials are not addressing new research questions, he said; they are trying to get proprietary drugs approved.Source: The New York Times
Study of ramucirumab plus pembrolizumab shows promise in NSCLC
In a phase I clinical trial, patients with previously treated advanced non-small cell lung cancer (NSCLC) have showed initial response and disease control from the drug combination of ramucirumab and pembrolizumab. Roy S. Herbst, MD, PhD, Chief of Medical Oncology at Yale Cancer Center and Smilow Cancer Hospital at Yale New Haven, will present the interim data of the clinical trial at the European Society for Medical Oncology (ESMO) Congress today.
Medulloblastoma patients should receive both chemotherapy and radiation post-surgery
In a recent study, a Yale Cancer Center team revealed that the addition of chemotherapy to postoperative treatment for adults with medulloblastoma improves survival. The benefit of chemotherapy, in addition to craniospinal radiation, was seen in adult patients with medulloblastoma (MB), including those with localized disease who received high-dose radiation treatment following surgery. The findings were presented September 26 at the American Society for Therapeutic Radiology and Oncology (ASTRO) meeting in Boston.
Yale Team Compares Effectiveness of Four PD-L1 Tests
In a recent study, a Yale Cancer Center team compared the performance of the four available PD-L1 assay tests. They found that one of the assays failed to reveal comparable levels of PD-L1, a tumor-promoting protein, while three others revealed comparable levels. The findings were presented September 26 at the International Association for the Study of Lung Cancer (IASLC) 2016 Chicago Multidisciplinary Symposium in Thoracic Oncology in Chicago.
Pembrolizumab Approval Is Tip of the Iceberg for Immunotherapy in HNSCC
The recent approval of pembrolizumab (Keytruda) in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) following progression on a platinum-based chemotherapy was a significant advancement for the disease. However, the approval of the PD-1 inhibitor only scratches the surface of the potential of immunotherapies in head and neck cancer, said Barbara A. Burtness, MD.Source: OncLive
Innovation to Impact: Dr. Lieping Chen and NextCure
Dr. Lieping Chen is a pioneer in the field of immuno-oncology and his discoveries have led to life-saving drugs for cancer patients. Now, with the support of the Yale Office of Cooperative Research, Dr. Chen has launched a startup—NextCure—that is poised to lead to even more breakthrough treatments.
A New Yale Faculty Startup Will Harness the Immune System to Fight Disease
Dr. David Spiegel, Professor of Chemistry and Pharmacology at Yale, is launching a new startup, Kleo Pharmaceuticals (link is external), that will harness the body’s own defenses to fight a number of diseases. Kleo relies on Spiegel’s patented immunotherapies—small molecules that can either recruit antibodies to a disease site or mimic the function of antibodies.Source: Office of Cooperative Research
Dr. Herbst on Next-Generation Agents in NSCLC
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor of Pharmacology, chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital, associate director for Translational Research, Disease Alligned Research Team Leader, Thoracic Oncology Program, Yale Cancer Center, discusses the next generation of agents coming down the pipeline in non–small cell lung cancer (NSCLC).Source: OncLive
First-Line Nivolumab Could Be Good Option in Lung Cancer
Two parts of a phase I trial found that nivolumab could be a good first-line treatment option for patients with advanced non–small-cell lung cancer (NSCLC). In one part of the study, the immunotherapy agent yielded good safety results and durable responses as monotherapy, and in the other, nivolumab combined with platinum-based doublet chemotherapy had more toxicity but again good responses.Source: Cancer Network
Study: Receptor suppresses the immune response in order to save it
When viruses enter the body, they activate receptors on the surface of cells that allow viruses to invade those cells. A Yale-led team has found that one of the receptors, known as AXL, actually plays an essential role in the immune system’s ability to fight viral infections.
A Connecticut Woman’s Tragedy Inspires Breakthroughs in Immunotherapy Cancer Treatment at Yale
“There’s a major, major change in the way in which we’re approaching all cancers. I think we will see over the next 10 and 20 years significant strides in what we can do for cancer. One goal of cancer care is can you turn cancer into a chronic condition? Or even can we cure metastatic cancer? Although we’re not there yet we’re certainly making strides,” said Yale Cancer Center's Dr. Scott Gettinger. If that happens it would be the ultimate legacy for Melissa’s spirit.Source: Connecticut Magazine