Big Pharma Bets on Body’s Garbage-Disposal System to Beat Cancer
At their most basic level, many of the deadliest diseases are caused by nests of misguided proteins. Most medicines work by attaching themselves to these proteins and temporarily shutting them down. In the 1990s, Yale University scientist Craig Crews and a colleague had a radical idea: What if a drug could destroy a bad protein by making it a target of the body’s own molecular trash disposal machines?
Regulatory Approvals and the Future of Cancer Care With Vincent DeVita
Vincent DeVita, MD, professor of medicine at Yale Cancer Center and former president of ACS, debates with Chadi some of the ideas laid out in his book, "The Death of Cancer," most notably the utility of randomized controlled trials in regulatory approvals.
Yale Cancer Center researchers show genetic mutations in advanced lung cancer may predict improved outcomes
According to new findings by Yale Cancer Center scientists, higher levels of genetic mutations in a tumor biopsy are linked to improved clinical outcomes in patients using pembrolizumab (Keytruda) to treat non-small cell lung cancer (NSCLC). The findings were presented today at the European Society for Medical Oncology (ESMO) conference in Barcelona, Spain.
Running road races helped Glastonbury woman power through breast cancer
As a kid, April Lionberger was usually the last to get picked for a team during gym class. But after her diagnosis for breast cancer at 36, she became a runner. She had exercised five days a week, but didn’t run. After being diagnosed with Stage 2 cancer, she met a woman training for a 5K during an exercise class for cancer survivors.
When cancer diagnosis causes spouse to retreat, seek support elsewhere, experts say
It’s not uncommon for a cancer diagnosis to expose cracks in a relationship, says Ellen A. Dornelas, author of “Psychological Treatment of Patients With Cancer.” Some people are undemonstrative because they’re uncomfortable expressing feelings, mental health therapists say. “There are some people in your life that are just not good at providing emotional support but they’re great at watching the kids or fixing the meal,” says Dwain Fehon, chief psychologist at Yale Cancer Center/Smilow Cancer Hospital. “We all know how frustrating it is to expect something from someone who is not the best to provide that for you.”
Surgical technique helps breast cancer patients avoid repeat surgeries
In breast cancer surgery, taking just a little bit more healthy tissue initially can help patients avoid a return trip to the operating room. This surgical technique, known as resection of cavity shave margins, has been shown to reduce the rate of cancerous margins of a breast cancer surgical specimen and the need for repeat surgery by half in women undergoing breast conserving surgery. In this technique, surgeons remove additional tissue in the circumference of the cavity left by a partial mastectomy.