Study to Assess Clinical Activity of Zelenectide Pevedotin in Participants With Advanced Breast Cancer
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Health Professionals
What is the purpose of this trial?
This is a global, multicenter, open-label study that aims to assess the efficacy and safety of zelenectide pevedotin in participants with NECTIN4-amplified recurrent, unresectable, or metastatic breast cancer who have received prior therapy (see inclusion criteria below). The study will comprise of 2 cohorts. Cohort A will include participants with hormone receptor positive/ human epidermal growth factor receptor 2 negative [HR+/HER2-] breast cancer, whereas Cohort B will include participants with triple-negative breast cancer (TNBC).
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Principal Investigator
Sub-Investigators
- Adriana Kahn, MD
- Alice Mookerjee
- Andrea Silber, MD
- Anita Kohli, MD
- David Silverstone, MD
- Eric Winer, MD
- Gargi Khare Vora, MD
- Gineesha Abraham
- Ian Krop, MD, PhD
- Jing Du, MD, PhD
- Katelyn Scott
- Kathryn Mason
- Maryam Lustberg, MD, MPH
- Maryam Tahvildari
- Melissa Gambaccini, APRN, AOCNP, FNPC
- Michael DiGiovanna, MD, PhD
- Michelle Corso
- Paul Clark Kang, MD
- Sarah Elizabeth Schellhorn, MD
- Soshian Sarrafpour, MD
- Tara Sanft, MD
- Vanna Dest
- Yvonne Wang, MD
- Last Updated11/05/2025
- Study HIC#2000039480