Colon, Phase III
A Phase 3, Open-Label, Randomized Study of Perioperative Dostarlimab Monotherapy Versus Standard of Care in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Volunteers
Health Professionals
What is the purpose of this trial?
The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon cancer.
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Anca Bulgaru, MD
- Andrea Brennan
- Armand Russo, MD
- Benjamin Newton, MD
- Clarice Grens
- D. Barry Boyd, MD, MS
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Jacquelyne Gaddy, MD, MSc, MSCR
- Jason Haldas, MD
- Jill Lacy, MD
- Johanna LaSala, MD
- Jose Morales-Marin
- Justin Persico, MD
- Katelyn Scott
- Kayla Martello
- Kristen Hoxie
- Larisa Fleysher
- Laura Sabourin
- Laura Van Metre Baum, MD, MPH
- M. Sung Lee, MD
- Madeline Santiago
- Matthew Austin, MD
- Megan Shulman
- Michael Burke
- Michael Cecchini, MD
- Michael Cohenuram, MD
- Neal Fischbach, MD
- Osarugue Otasowie
- Pamela L. Kunz, MD
- Pawan Karanam, MD
- Robert Legare, MD
- Sara Anastasio, RN
- Sarah Carlson
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Teresa White
- Thejal Srikumar, MD, MPH
- Vanna Dest
- Vidya Kesavan
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Zia Rahman, MD
- Last Updated07/04/2025
- Study HIC#2000037423