The following is a comprehensive list of Yale Urology publications/presentations for the second quarter of calendar year 2025. The listing is in descending published date order and features primary faculty and trainee work. Each item includes links to the full study or presentation and provides portions of the abstract/summary.
Sundaresan VM, Leapman MS. Debate 1: Radical Prostatectomy For the Right Patient With High-Risk Prostate Cancer. Semin Radiat Oncol. 2025 Jul;35(3):385-392. doi: 10.1016/j.semradonc.2025.05.001. PMID: 40516973.
In this article, we distill the following 5 evidence-based arguments that commonly motivate patients to select radical prostatectomy as initial treatment of 'high-risk' prostate cancer. The first is that surgery alone provides excellent long-term cancer control and disease-related survival. Second, radical prostatectomy provides definitive local and regional disease staging, serving as the backbone for multimodality treatment if needed. Third, the sequencing of surgery before radiation is viewed as preferable beca by preserving options for effective local salvage. Fourth, initial surgery successfully defers or avoids the adverse effects of long-term androgen deprivation therapy in a substantial proportion of patients. Lastly, fifth, prostatectomy offers manageable impacts on urinary and sexual function, minimizing risk of gastrointestinal toxicity or secondary malignancy, and averts local symptomatic progression in most.
Zeevi T, Lieffrig EV, Staib LH, Onofrey JA. Spatially-Aware Evaluation Of Segmentation Uncertainty. arXiv. Jun 19. doi:10.48550/arXiv.2506.16589
We propose three spatially aware metrics that incorporate structural and boundary information and conduct a thorough validation on medical imaging data from the prostate zonal segmentation challenge within the Medical Segmentation Decathlon.
Frumer M, Ben-Meir D, Shenhar C, Peard L, Buchanan AF, Hittelman AB, Franco I. Utilization of the modified Bosniak classification system for complex renal cysts. Pediatr Nephrol. 2025 Jun 12. doi: 10.1007/s00467-025-06848-5. Epub ahead of print. PMID: 40504241.
To conduct a meta-analysis of the literature on the modified Bosniak (mBosniak) classification system to assess its diagnostic performance in pediatric complex renal cysts.
Smani S, Khan AI, Choksi AU, Press BH, Rahman SN, Hayden CS, Gardezi M, Jalfon M, Lee J, Sprenkle PC, Kellner DS. Can Anatomical Measurements on Preoperative Pelvic Magnetic Resonance Imaging Predict Postoperative Urinary Incontinence after Holmium Laser Enucleation of the Prostate? J Endourol. 2025 Jun 5. doi: 10.1089/end.2025.0006. Epub ahead of print. PMID: 40470526.
This study aimed to evaluate the predictive value of preoperative anatomical measurements, including membranous urethral length (MUL), membranous urethral angle (MUA), levator ani thickness (LAT), and intravesical prostatic protrusion length (IPPL), in assessing the risk of early postoperative urinary incontinence following HoLEP.
Lokeshwar SD, Choksi AU, Smani S, Heacock D, Kanaparthy NS, Shaheen DM, Dashevsky M, Martin T, Singh D, Motamedinia P, Sangal R. A Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes. Urol Pract. 2025 Jun 3:101097UPJ0000000000000847. doi: 10.1097/UPJ.0000000000000847. Epub ahead of print. PMID: 40459510.
This retrospective cohort study examined patients presenting with renal colic or ureteral stones at 9 EDs in a northeast health system between January 1 and December 31, 2023.
Cahill EM, Patel HV, Koch GE, Sterling J. Antibiotic Prophylaxis After Urethroplasty: A Review of the Literature. J Clin Med. 2025 Jun 2;14(11):3915. doi: 10.3390/jcm14113915. PMID: 40507677; PMCID: PMC12156196.
There are currently no established guidelines for the management of antibiotics for patients undergoing urethroplasty, specifically with regard to postoperative prophylaxis through the time of foley catheter removal. In this review, we examine the current literature regarding antibiotic prophylaxis and urethroplasty.
Cueto LN [Ghali F]. Publication and data sharing of completed NCI cooperative group trials. Journal of clinical oncology. 06/2025;43(16_suppl):11023-11023. doi: 10.1200/jco.2025.43.16_suppl.11023.
We examined the dissemination of NCI cooperative group trial results via published manuscripts as well as availability of IPD from completed trials.
Ross A, [Leapman M]. Real-world analysis of primary tumor transcriptomes in patients subsequently treated with PARP inhibitors. Journal of clinical oncology. 06/2025;43(16_suppl). doi: 10.1200/jco.2025.43.16_suppl.e17140.
In this real-world study of patients initially presenting with non-metastatic disease who subsequently received PARP inhibitors, transcriptome analysis from the primary tumor revealed the presence of adverse molecular features when disease was still localized. Patients with higher Decipher score, p53 mutation signature and PTEN inactivation tumors at initial testing, could be considered for additional confirmatory genomic or genetic testing and potentially novel trials of PARPi.
Palencia PS [Smani S, Sivanesan N, Cavallo J, Leapman M] . Association between prostate radiation therapy and survival among patients with metastatic prostate cancer by extent of disease burden. Journal of clinical oncology. 06/2025;43(16_suppl). doi: 10.1200/jco.2025.43.16_suppl.e17123.
We conducted a retrospective analysis of the National Cancer Database to identify individuals newly diagnosed with metastatic prostate cancer, all of whom were treated with androgen deprivation therapy (ADT).
Kashima S, [Kenney PA]. Investigation of tumor-associated macrophages (TAMs) and therapeutic resistance to immune checkpoint inhibitors (ICI) through single-cell analysis of renal cell carcinoma (RCC). Journal of clinical oncology. 06/2025;43(16_suppl):4527-4527. doi: 10.1200/jco.2025.43.16_suppl.4527.
This study investigates tumor-associated macrophages (TAMs) in renal cell carcinoma (RCC) and their role in resistance to immune checkpoint inhibitors (ICIs) through single-cell analysis. The research identifies specific TAM populations, particularly the LILRB/SIGLEC10-TAM subcluster, that are associated with ICI treatment resistance, providing insights for potential therapeutic targets in RCC.
Bortnick EM, Wills K, Nelson CP. Simulation-based education of the male infant genitourinary physical exam and management of undescended testis. J Pediatr Urol. 2025 May 31:S1477-5131(25)00301-8. doi: 10.1016/j.jpurol.2025.05.029. Epub ahead of print. PMID: 40537314.
We hypothesized that asynchronous didactics and simulation-based learning would improve pediatrician confidence, comfort, and skill performing the GUPE and increase knowledge on UDT management.
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S. Kappa. Opioid Receptor Antagonism Restores Phosphorylation, Trafficking and Behavior induced by a Disease Associated Dopamine Transporter Variant. bioRxiv [Preprint]. 2024 May 29:2023.05.03.539310. doi: 10.1101/2023.05.03.539310. Update in: Mol Psychiatry. 2025 May 29. doi: 10.1038/s41380-025-03055-4. PMID: 37205452; PMCID: PMC10187322.
Here we demonstrate that KOR stimulation leads to enhanced surface trafficking and phosphorylation of Thr53 in wildtype DAT, effects achieved constitutively by the Val559 mutant.
Jiang Y, Cheng S, Li L, Fraidenburg M, Kim IY, Deng S, Mu P. Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer. bioRxiv [Preprint]. 2025 May 29:2025.05.26.656166. doi: 10.1101/2025.05.26.656166. PMID: 40501767; PMCID: PMC12154883.
This study investigates the role of Notch signaling in mediating lineage plasticity and therapeutic resistance in CRPC. Employing transcriptomic analysis and functional assays, we identified Notch activity is elevated across prostate cancer progression resistance.
Kwaramba T [Leapman M]. Risk and predictors of late second primary malignancies in long-term breast, prostate, colon, and rectal cancer survivors. Journal of clinical oncology. 06/2025;43(16_suppl):1642-1642. doi: 10.1200/jco.2025.43.16_suppl.1642.
This study aims to quantify SPM risk, identify predictors, and describe prevalent SPM sites in older survivors of breast, prostate, colon, and rectal cancer to guide survivorship care.
Cai L, Rogers TJ, Mousavi Jafarabad R, Vu H, Yang C, Novaresi N, Galán-Cobo A, Girard L, Ostrin EJ, Fahrmann JF, Kim J, Heymach JV, O'Donnell KA, Xiao G, Xie Y, DeBerardinis RJ, Minna JD. High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas. Cancers (Basel). 2025 May 16;17(10):1681. doi: 10.3390/cancers17101681. PMID: 40427178; PMCID: PMC12109616.
KYNU is a robust prognostic biomarker and potential immunometabolic target in LUAD, especially in STK11 and KEAP1 co-mutated tumors. Its cancer cell-intrinsic expression and immunosuppressive metabolic phenotype offer translational potential, though species-specific expression patterns pose challenges for preclinical modeling.
Miszczyk M, Fazekas T, Rajwa P, Matsukawa A, Tsuboi I, Leapman MS, Kramer G, Hussain M, Merseburger A, Briganti A, D'Amico AV, Gillessen S, Saad F, Shariat SF. Prostate-specific Antigen Response as a Prognostic Factor for Overall Survival in Patients with Prostate Cancer Treated with Androgen Receptor Pathway Inhibitors: A Systematic Review and Meta-analysis. Eur Urol Focus. 2025 May 15:S2405-4569(25)00075-6. doi: 10.1016/j.euf.2025.03.019. Epub ahead of print. PMID: 40379533.
For patients with advanced prostate cancer (PC) treated with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor (ARPI), the decline in prostate-specific antigen (PSA) is a potential biomarker for treatment response. We synthesised data regarding the association of the PSA response with overall survival (OS).
Wong LM, Hu JC, Zhao L [Onofrey JA]. Equivariant Imaging Biomarkers for Robust Unsupervised Segmentation of Histopathology. arXiv. Published May 9, 2025. doi:10.48550/arxiv.2505.05689
In this work, we address these limitations and make the following contributions: (1) apply equivariant feature learning to learn robust histopathologic imaging biomarkers that are resilient to rotations; (2) develop an unsupervised learning pipeline to perform equivariant biomarker-based segmentation in the absence of manual ground-truth annotations; and (3) validate our approach on a prostate tissue micro-array (TMA) dataset.
Khondker A, Kim JK, Arlen AM, Rickard M, Chua ME, Kirsch AJ, Lorenzo AJ, Cooper CS. Early spontaneous resolution of vesicoureteral reflux from voiding cystourethrogram: A comparison of contemporary prediction models. J Pediatr Urol. 2025 May 2:S1477-5131(25)00257-8. doi: 10.1016/j.jpurol.2025.04.030. Epub ahead of print. PMID: 40368726.
Contemporary predictive models, such as VURx, ureteral diameter ratio (UDR), and qVUR have been developed to improve risk stratification and guide decision-making. Here, we incorporated these measures to improve prediction of VUR resolution.
Sivanesan N, Diaz GM, Sprenkle PC. Tissue-based gene expression testing in localized prostate cancer. Curr Opin Urol. 2025 Jul 1;35(4):432-438. doi: 10.1097/MOU.0000000000001289. Epub 2025 May 2. PMID: 40314067.
This review presents the latest research in tissue-based genomic testing in localized prostate cancer (PCa). Here we explore the current and most commonly used genomic assays, their clinical applications, current challenges, and the future of genomic testing.
Choksi A, Hricko K, Lokeshwar S, Mazzarelli L, Renzulli J, Brito J. MP17-16 DIAGNOSTIC ACCURACY OF CONTRAST ENHANCED RENAL ULTRASOUND AS AN ADJUNCT TO SMALL RENAL MASS CHARACTERIZATION. Journal of Urology [Internet]. 2025 May 1 [cited 2025 Jul 8];213(5S):e594. Available from: https://doi.org/10.1097/01.JU.0001109912.49042.ad.16
Contrast Enhanced Ultrasound (CEUS) is an emerging radiographic technique which involves the administration of intravenous microbubbles to evaluate the microvasculature of the kidney and liver. Its use in the characterization of small renal masses is increasing. In this study, we compare the diagnostic accuracy of renal CEUS to pathology at time of biopsy or surgery.
Smani S, Lokeshwar SD, Palencia PS, Ajjawi I, Sivanesan N, Leapman MS. PD18-07 NATIONAL PATTERNS OF FOCAL THERAPY USE AMONG PATIENTS WITH PROSTATE CANCER. Journal of Urology [Internet]. 2025 May 1 [cited 2025 Jul 8];213(5S):e626. Available from: https://doi.org/10.1097/01.JU.0001109928.76203.bd.07
A retrospective cohort study of the National Cancer Database (NCDB) was conducted to identify patients diagnosed with clinically localized PCa between 2004 and 2021.
Smani S [Lokeshwar SD, Sprenkle P, Leapman, MS]. 1694 association between prostate MRI PI-RADS classification and risk of gleason upgrade during active surveillance: A systematic review and meta-analysis. Radiotherapy and oncology. 05/2025;206:S1969-S1970. doi: 10.1016/s0167-8140(25)00610-3.
This study aims to evaluate the prognostic significance of baseline mpMRI findings and the risks of disease reclassification in patients with favorable-risk PCa undergoing active surveillance.
Kim IE Jr, Brito J, Renzulli J, Sprenkle P, Leapman MS, Kim IY. MP07-09 Lack Of Survival Benefit Of Pelvic Lymph Node Dissection For Radical Prostatectomy Patients Who Underwent Radiotherapy. Journal of Urology [Internet]. 2025 May 1 [cited 2025 Jul 8];213(5S):e234. Available from: doi:10.1097/01.JU.0001109784.58660.a5.09
The survival benefit of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains unclear, as PLND can result in significant morbidity. Thus, the objective of this study was to evaluate the overall survival (OS) of PLND and extended PLND for RP patients who later underwent radiotherapy.
Lokeshwar SD, Pfail J, Smani S, Palencia P, Sohoni N, Ann Balistreri S, [Kim IY]. MP22-17 Randomized Three-Arm Trial To Evaluate The Effect of Neoadjuvant Apalutamide Alone Or In Combination With Abiraterone Acetate And GNRH Agonist On Enhancing Surgical Outcome Of Nerve-Sparing Radical Prostatectomy In Men With High-Risk Prostate Canc. Journal of Urology [Internet]. 2025 May 1;213(5S):e790. Available from: https://doi.org/10.1097/01.JU.0001109988.34650.0d.17
The hypothesis was that neoadjuvant Apalutamide will result in downstaging of disease and allow a better sparing of the neurovascular bundles.
Sivanesan N, Diaz GM, Kandala K, Sprenkle PC. MP09-20 Assessing The Accuracy And Reproducibility of Chat GPT Answers About Prostate Cancer, Screening, And Diagnosis. Journal of Urology [Internet]. 2025 May 1; 213(5S):e261. Available from: https://doi.org/10.1097/01.JU.0001109792.00985.9d.20
The objective of this study is to evaluate the responses given by Chat GPT pertaining to prostate cancer (PCa) to ensure that they avoid fostering beliefs based on inaccurate information.
Palencia PS, Rabil MJ, Jalfon M, Heckscher D, Richmond R, Kong V, [Golos A, Leapman M, Cavallo JA]. MP33-07 Automated Abstraction Algorithm For Radical Cystectomy Surgical Outcomes. Journal of Urology [Internet]. 2025 May; 213(5S):e1131. Available from: https://doi.org/10.1097/01.JU.0001110116.40703.0e.07
We hypothesized that a novel electronic medical record (EMR)-based automated algorithm would demonstrate>90% sensitivity and specificity with significant inter-rater reliability with institutional National Surgical Quality Improvement Program (NSQIP) data abstraction.
Cahill E, Honig SC, Reddy S, Fernandez A, Schroeder T, Kaur I, [Rotker K]. IP18-28 Is A Fresh Semen Analysis Necessary For A Post Vasectomy Semen Analysis?: Assessment Of Stability Of Sperm Concentration Over A 10-Day Time Frame As A Model For Post Vasectomy Semen Analysis Using The Fellow System. Journal of Urology [Internet]. 2025 May 1; 213(5S):e976. Available from: https://doi.org/10.1097/01.JU.0001110060.12139.1b.28
The purpose of this study is to evaluate whether any low concentration specimens reduce to zero when evaluated over a 10-day period.
Olawoyin OM, Choksi AU, Cahill EM, Weiss RM, Arlen AM. MP26-06 Does It Really Matter? Outcomes Of Scrotal Exploration For Testicular Torsion Performed By Pediatric Urologists Vs. Adult Urologists. Journal of Urology [Internet]. 2025 May 1; 213(5S):e916. Available from: https://doi.org/10.1097/01.JU.0001110036.00487.3f.06
We aim to analyze differences in outcomes of surgical exploration for torsion performed by a pediatric urologist vs. an adult urologist.
Cedars B, Sterling J, Nikolavsky D. V01-4 Dorsal Onlay BMG Urethroplasty For VUAS After Radiation And Prostatectomy. Journal of Urology [Internet]. 2025 May 1;213(5S):e56. Available from: https://doi.org/10.1097/01.JU.0001109724.97610.92.04
Based on our experience with dorsal onlay BMG for membranous urethral strictures with continence preservation, we propose that this technique can be used safely and effectively in radiated post-prostatectomy fields.
Diaz GM, Sivanesan N, Sohoni N, DuBois J, Strachan S, Martin DT, [Sprenkle PC, Leapman MS]. IP25-20 Sociodemographic Disparities in Tissue-Based Genomic Testing For Prostate Cancer. Journal of Urology [Internet]. 2025 May 1 [cited 2025 Jul 8];213(5S):e1291. Available from: https://doi.org/10.1097/01.JU.0001110172.53107.6f.20.
We aimed to evaluate patient and area-level sociodemographic factors associated with the use of GC testing for localized prostate cancer (PCa).
Cahill EM, Honig SC, Reddy S, Nolte D, Kenfield S, Belarmino A, [Rotker K]. IP18-29 Mail-In Semen Analysis VS Fresh Sample For Post-Vasectomy Semen Analysis (PSVA): Identifying An Efficient Approach To Achieving Post-Vasectomy Clearance. Journal of Urology [Internet]. 2025 May 1;213(5S):e977. Available from: https://doi.org/10.1097/01.JU.0001110060.12139.1b.29
The objective of our study was to evaluate the % of patients that required repeat mail-in testing compared to a single, fresh PVSA sample.
Markhong Y, Sprenkle P, Pavlovich C, Klotz L, Scionti S, Pathak R... MP06-19 Deep Learning Prostate Segmentation Module To Assist In MRi-Guided Transurethral Ultrasound (TULSA) Treatment Planning: Validation Study And Real-World Performance Journal of Urology [Internet]. 2025 May 1; 213(5S):e151. Available from: https://doi.org/10.1097/01.JU.0001109752.81014.18.19
We present a multi-reader multi-case (MRMC) study validating the accuracy and time savings of an AI model for automatic segmentation of the prostate, and real-world treatment planning times after FDA clearance of the AI contouring tool.
Buck MB, Smani S, Nguyen J, Abello A, Jalfon M, Lokeshwar SD, Leapman MS, Cavallo JA, Kenney PA. Antibiotic prophylaxis prior to office-based urologic procedures: outcomes from a department-wide quality improvement project. World J Urol. 2025 Apr 29;43(1):257. doi: 10.1007/s00345-025-05642-0. PMID: 40299076.
We hypothesized that a risk-adapted approach would reduce prophylactic antibiotic utilization and practice variability without increasing febrile UTI rates.
Jiang Y, Cheng S, Kim IY, Deng S, Mu P. Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity. bioRxiv [Preprint]. 2025 Apr 23:2025.04.18.649575. doi: 10.1101/2025.04.18.649575. PMID: 40488132; PMCID: PMC12143872.
Through comprehensive bioinformatic analysis of multi-omics data-including expression profiles of 39 HOX genes from over 80,000 RNA sequencing samples across 114 cancer types-we first demonstrated that HOX codes effectively represent the lineages of cancer cells.
Zhu J, Wang Y, Chang WY, Malewska A, Napolitano F, Gahan JC, Unni N, Zhao M, Yuan R, Wu F, Yue L, Guo L, Zhao Z, Chen DZ, Hannan R, Zhang S, Xiao G, Mu P, Hanker AB, Strand D, Arteaga CL, Desai N, Wang X, Xie Y, Wang T. Mapping cellular interactions from spatially resolved transcriptomics data. Nat Methods. 2024 Oct;21(10):1830-1842. doi: 10.1038/s41592-024-02408-1. Epub 2024 Sep 3. PMID: 39227721.
We evaluated the fitness of Spacia for three commercialized single-cell resolution SRT technologies: MERSCOPE/Vizgen, CosMx/NanoString and Xenium/10x. Overall, Spacia represents a notable step in advancing quantitative theories of cellular communications.
Zeevi T [Onofrey JA]. Enhancing uncertainty estimation in semantic segmentation via monte-carlo frequency dropout. 04/2025:1-5. doi: 10.1109/isbi60581.2025.10980684.
A novel approach extends Dropout to the frequency domain, allowing stochastic attenuation of signal frequencies during inference. This creates diverse global textural variations in feature maps while preserving structural integrity - a factor we hypothesize and empirically show is contributing to accurately estimating uncertainties in semantic segmentation.
Du Y [Onofrey JA]. SRE-CONV: Symmetric rotation equivariant convolution for biomedical image classification. 04/2025:1-5. doi: 10.1109/isbi60581.2025.10981270
We propose a novel and efficient implementation of the Symmetric Rotation-Equivariant (SRE) Convolution (SRE-Conv) kernel, designed to learn rotation-invariant features while simultaneously compressing the model size.
Zhong J [Onofrey JA]. Conditional convolution of clinical data embeddings for multimodal prostate cancer classification. 04/2025:1-5. doi: 10.1109/isbi60581.2025.10981307.
In this study, we introduce EmbedCondConv a novel multimodal GS prediction model that incorporates clinical information by conditioning CNN kernels on principal components derived from patient clinical data.
Zhang J [Onofrey JA]. Improved vessel segmentation with symmetric rotation-equivariant U-net. 04/2025:1-5. doi: 10.1109/isbi60581.2025.10981208.
Our proposed SRE U-Net not only significantly surpasses standard U-Net in handling rotated images, but also outperforms existing equivariant learning methods and does so with a reduced number of trainable parameters and smaller memory cost.
Gardezi M, Sanekommu G, Lee JJ. Ergonomic Challenges and Considerations in Endoscopic Treatment of Benign Prostatic Hyperplasia. Curr Urol Rep. 2025 Apr 15;26(1):37. doi: 10.1007/s11934-025-01266-4. PMID: 40232581.
The present review explores the prevalence of musculoskeletal work-related injuries associated with endoscopic treatment of benign prostatic hyperplasia, ergonomic factors and potential current and future solutions.
Sivanesan N, Diaz GM, Kandala K, Tan WS, Sprenkle PC. Why prompting matters: achieving clinically accurate and consistent responses with Chat GPT. BJU Int. 2025 Apr 14. doi: 10.1111/bju.16738. Epub ahead of print. PMID: 40223543.
In this study, we aimed to assess the accuracy and reliability of Chat GPT's responses concerning prostate cancer to ensure they do not provide misinformation with the objective to enhance the overall quality of AI-driven medical communication.
Smani S, DuBois J, Ajjawi I, Sohoni N, Choksi AU, Lokeshwar SD, Kim IY, Renzulli JF. Advances in Current Treatment Paradigms for Metastatic Hormone-Sensitive Prostate Cancer. J Clin Med. 2025 Apr 8;14(8):2565. doi: 10.3390/jcm14082565. PMID: 40283395; PMCID: PMC12028174.
The role of treatment of the primary tumor, by either radiation therapy or cytoreductive prostatectomy, in low-volume disease continues to be explored. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential.
Do LK, Lee HM, Ha YS, Lee CH, Kim J. Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches. Cell Rep. 2025 Apr 22;44(4):115529. doi: 10.1016/j.celrep.2025.115529. Epub 2025 Apr 6. PMID: 40193251; PMCID: PMC12038367.
This overview discusses the current findings on the heterogeneity in amino acid metabolism in cancer and how understanding the metabolic diversity of amino acids can be translated into more clinically relevant therapeutic interventions.
Brock GB, Hellstrom WJG, Giraldi A, Honig S. Addressing unmet needs for patients with erectile dysfunction: a narrative review of topical therapies. Sex Med. 2025 May 12;13(2):qfaf021. doi: 10.1093/sexmed/qfaf021. PMID: 40356742; PMCID: PMC12066416.
The objective of this paper is to evaluate topical therapies for ED used in clinical studies, either as single agents or in combination with a PDE5i, and consequently determine which topical therapies meet the criteria of an 'ideal medication for ED.'
[Onofrey JA] GMR-conv: An efficient rotation and reflection equivariant convolution kernel using gaussian mixture rings. arXiv. 2025.
In this work, we introduce Gaussian Mixture Ring Convolution (GMR-Conv), an efficient convolution kernel that smooths radial symmetry using a mixture of Gaussian-weighted rings. This design mitigates discretization errors of circular kernels, thereby preserving robust rotation and reflection equivariance without incurring computational overhead.
Garg A [Hittelman A]. 5. A rare case of 45X/46XY mosaic turner syndrome in a neonate. Journal of pediatric & adolescent gynecology. 04/2025;38(2):232. doi: 10.1016/j.jpag.2025.01.038.
Ambiguous genitalia in a newborn can be challenging to diagnose and manage. We present a case of a 2-month-old infant with atypical genitalia and genetic (45X/46XY) mosaicism.