Michael S. Leapman, MD, MHS
Cards
Appointments
Titles
Clinical Program Leader, Prostate & Urologic Cancers Program, Yale Cancer Center; Assistant Professor, Chronic Disease Epidemiology
Contact Info
Urology
PO Box 208058
New Haven, CT 06520-8058
United States
Appointments
Titles
Clinical Program Leader, Prostate & Urologic Cancers Program, Yale Cancer Center; Assistant Professor, Chronic Disease Epidemiology
Contact Info
Urology
PO Box 208058
New Haven, CT 06520-8058
United States
Appointments
Titles
Clinical Program Leader, Prostate & Urologic Cancers Program, Yale Cancer Center; Assistant Professor, Chronic Disease Epidemiology
Contact Info
Urology
PO Box 208058
New Haven, CT 06520-8058
United States
About
Titles
Associate Professor of Urology
Clinical Program Leader, Prostate & Urologic Cancers Program, Yale Cancer Center; Assistant Professor, Chronic Disease EpidemiologyBiography
Clinical interests: Prostate cancer: low-risk prostate cancer, active surveillance, nerve-sparing robotic prostatectomy, focal therapy, high-risk disease, pelvic lymph node dissection, imaging, risk stratification; molecular imaging; PSMA; focal therapy; bladder cancer: intravesical therapy, TURBT, radical cystectomy with urinary diversion, continent urinary diversion, neobladder, ileal conduit. Kidney cancer: laparoscopic radical nephrectomy, laparoscopic partial nephrectomy, robotic partial nephrectomy, open radical nephrectomy, open partial nephrectomy. Testicular cancer. Upper tract urothelial carcinoma: laparoscopic, open nephroureterectomy, ureterectomy Watch a video with Dr. Michael Leapman >>
Michael Leapman, MD was drawn to the field of urology for the opportunity to care for patients with urologic cancers. He aims, above all, to deliver the highest level of care possible with the utmost consideration and compassion for the impact that cancer places on patients, as well as their families, friends and communities.
Dr. Leapman graduated from Cornell University where he majored in Neurobiology and Behavior, and received his medical school degree from the University of Maryland in Baltimore. He completed his General Surgery and Urology training at the Mount Sinai Hospital in New York, NY. Subsequently, he completed a urologic oncology fellowship at the University of California San Francisco (UCSF) accredited by the Society of Urologic Oncology. He joined the faculty at the Yale University School of Medicine and Yale Cancer Center in 2016, specializing in urologic oncology with a joint appointment at the West Haven Veterans Affairs Medical Center.
Appointments
Urology
Associate Professor on TermPrimaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
Education & Training
- MHS
- Yale University (2022)
- Fellowship
- University of California San Francisco (2016)
- Residency
- Mount Sinai Medical Center (2014)
- Internship
- Mount Sinai Medical Center (2010)
- MD
- University of Maryland School of Medicine (2009)
- BA
- Cornell University (2005)
Research
Overview
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Preston C. Sprenkle, MD
Cary Gross, MD
Patrick A. Kenney, MD
Xiaomei Ma, PhD
Michaela Dinan, PhD
Henry S. Park, MD, MPH
Prostatic Neoplasms
Urologic Neoplasms
Publications
Classification and Risk Factors for Surgical Site Infections in Radical Cystectomy: A 16-Year Analysis
Lokeshwar S, Choksi A, Smani S, Ip K, Javier-DesLoges J, Rahman S, Leapman M, Martin T, Hesse D. Classification and Risk Factors for Surgical Site Infections in Radical Cystectomy: A 16-Year Analysis. Surgical Infections 2024 PMID: 38959160, DOI: 10.1089/sur.2024.107.Peer-Reviewed Original ResearchConceptsSurgical site infectionBody mass indexRadical cystectomyCenters for Disease Control and PreventionIndependent risk factorLength of stayRisk factorsAntibiotic agentsSite infectionCenters for Disease Control and Prevention classificationRisk factors of surgical site infectionFactors associated with surgical site infectionFactors of surgical site infectionPredictive of surgical site infectionDeep incision surgical site infectionSurgical site infection predictorsOdds ratioTreatment of surgical site infectionsDeep surgical site infectionPeri-operative characteristicsPeri-operative morbidityCharlson Comorbidity IndexLogistic regression analysisSuperficial incisionalDisease Control and PreventionRisk Factors and Contemporary Management Options for Pain and Discomfort Experienced During a Prostate Biopsy
Diaz G, Webb L, Rabil M, Lokeshwar S, Choksi A, Leapman M, Sprenkle P. Risk Factors and Contemporary Management Options for Pain and Discomfort Experienced During a Prostate Biopsy. Current Urology Reports 2024, 1-10. PMID: 38896314, DOI: 10.1007/s11934-024-01220-w.Peer-Reviewed Original ResearchAltmetricConceptsProstate biopsyRisk factorsEffective pain management strategiesDiagnosed prostate cancerPain management strategiesIn-office proceduresModern management optionsNonadherence to treatmentContemporary management optionsEnhance patient comfortInnovative imaging modalitiesExperience of painFusion biopsyProstate volumePain intensityProstate cancerPain varyPatient ageIncreased painFollow-upIn-officeManagement optionsSurveillance adherenceBiopsyPharmacological analgesicsChanges in Facility Share of Medicaid-Insured Patients with Urologic Cancers Following Implementation of the Patient Protection and Affordable Care Act
Demkowicz P, Buck M, Nie J, Marks V, Wheeler S, Dinan M, Gross C, Leapman M. Changes in Facility Share of Medicaid-Insured Patients with Urologic Cancers Following Implementation of the Patient Protection and Affordable Care Act. Urology 2024 PMID: 38901803, DOI: 10.1016/j.urology.2024.06.003.Peer-Reviewed Original ResearchCitationsConceptsFacility-level changesAffordable Care ActNon-expansion statesUrological cancer patientsProportion of patientsExpansion statesBaseline proportion of patientsUrologic cancer careHigh-income zip codesCancer patientsFactors associated with changesPre-post designCancer care centerPost-ACA periodMedicaid expansion statesMultivariate logistic regressionMedicaid-insured patientsCancer careUrological cancersZip codesCare ActMedicaid patientsMedicaidLogistic regressionCare centerDevelopment of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage
Leapman M, Ho J, Liu Y, Filson C, Zhao X, Hakansson A, Proudfoot J, Davicioni E, Martin D, An Y, Seibert T, Lin D, Spratt D, Cooperberg M, Ross A, Sprenkle P. Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage. JAMA Network Open 2024, 7: e2417274. PMID: 38874922, PMCID: PMC11179136, DOI: 10.1001/jamanetworkopen.2024.17274.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsElectronic health recordsCancer diagnosisClinical data linkageMedicine Clinical TermsPatterns of careProstate cancer diagnosisRadical prostatectomyCancer risk stratificationData linkageHealth recordsClinical dataMain OutcomesCancer outcomesClinical juncturesClinical careCommon Procedural Terminology codesAdministrative dataDiagnosis codesLongitudinal clinical dataCohort studyPharmacy recordsGenomic classifierProcedural Terminology codesDevelopment of prostate cancer metastasisLinkage dataAssociation between pelvic lymph node dissection and survival among patients with prostate cancer treated with radical prostatectomy
Kim I, Wang A, Corpuz G, Sprenkle P, Leapman M, Brito J, Renzulli J, Kim I. Association between pelvic lymph node dissection and survival among patients with prostate cancer treated with radical prostatectomy. Prostate International 2024, 12: 70-78. DOI: 10.1016/j.prnil.2024.01.002.Peer-Reviewed Original ResearchConceptsPelvic lymph node dissectionBenefit of pelvic lymph node dissectionGleason grade groupLymph node dissectionProstate cancer patientsRadical prostatectomyNode dissectionProstate cancer treated with radical prostatectomyCancer patientsAssociated with improved OSTime of radical prostatectomyGrade groupSurvival of prostate cancer patientsMedian PSA valuePre-operative characteristicsProstate cancer-specificTime of RPLog-rank testKaplan-Meier curvesPSA valuesSurvival benefitProstate cancerMedian ageClinical benefitCancer-specificMagnetic Resonance Imaging in Prostate Cancer Screening
Fazekas T, Shim S, Basile G, Baboudjian M, Kói T, Przydacz M, Abufaraj M, Ploussard G, Kasivisvanathan V, Rivas J, Gandaglia G, Szarvas T, Schoots I, van den Bergh R, Leapman M, Nyirády P, Shariat S, Rajwa P. Magnetic Resonance Imaging in Prostate Cancer Screening. JAMA Oncology 2024, 10: 745-754. PMID: 38576242, PMCID: PMC10998247, DOI: 10.1001/jamaoncol.2024.0734.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinically significant PCaDetection of clinically significant PcaInternational Society of Urological PathologyClinically significant PCa detectionProstate magnetic resonance imagingMagnetic resonance imagingInsignificant PCaProstate cancerProstate cancer screeningBiopsy indicationClinically significant PCa detection rateProstate-specific antigen (PSA)-based screeningMagnetic resonance imaging pathwayOdds ratioPCa detection rateSignificant PCaPI-RADS scorePSA-based screeningResonance imagingScreening pathwayTime of magnetic resonance imagingPositive predictive valuePooled odds ratioProspective cohort studyRandomized clinical trialsOpioid prescribing trends and pain scores among adult patients with cancer in a large health system.
Baum L, Soulos P, KC M, Jeffery M, Ruddy K, Lerro C, Lee H, Graham D, Liberatore M, Rivera D, Leapman M, Jairam V, Dinan M, Gross C, Park H. Opioid prescribing trends and pain scores among adult patients with cancer in a large health system. Journal Of Clinical Oncology 2024, 42: 11059-11059. DOI: 10.1200/jco.2024.42.16_suppl.11059.Peer-Reviewed Original ResearchConceptsDocumented painHealth systemOpioid prescribingOpioid prescriptionsOpioid prescribing trendsYale New Haven Health SystemPrescribing trendsMetastatic cancerDocumented pain scoresUS health systemOpioid usePain scoresAdult patientsCalculated predicted probabilitiesFlowsheet dataRetrospective cohort studyRelated harmSolid tumor malignanciesCohort studyCancer painPrescribingContext of cancer treatmentStudy criteriaPainSurgery cohortPersonalized risk assessment of new onset depression in long-term cancer survivors.
Taylor M, Westvold S, Long J, Hyslop T, Wang S, Cecchini M, Leapman M, Leeds I, Lustberg M, Spees L, Wheeler S, Gross C, Oeffinger K, Dinan M. Personalized risk assessment of new onset depression in long-term cancer survivors. Journal Of Clinical Oncology 2024, 42: e13798-e13798. DOI: 10.1200/jco.2024.42.16_suppl.e13798.Peer-Reviewed Original ResearchConceptsHistory of depressionIncidence of depressionCumulative incidence of depressionRisk of developing depressionLong-term survivorsPredictors of depressionCancer survivorsDisease specific factorsCumulative incidenceNon-HispanicHigher risk of developing depressionRectal cancerLong-term cancer survivorsBreast cancer survivorsCensus tract povertyColon cancerEpisodes of bipolar I disorderPrevalence of depressionMean survival time modelsDiagnosis of depressionReceipt of treatmentAssociated with prior historyHormone receptor statusPatients aged <Adjuvant endocrine therapyThe effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy
Lokeshwar S, Ali A, Weiss T, Reynolds J, Shuch B, Ferencz T, Kyriakides T, Mehal W, Brito J, Renzulli J, Leapman M. The effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy. BMC Urology 2024, 24: 102. PMID: 38702664, PMCID: PMC11067086, DOI: 10.1186/s12894-024-01483-y.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsEnd-of-studyProstate cancerRadical prostatectomyTreatment armsDouble-blind randomized trialProstate cancer characteristicsSurgical margin statusLocalized prostate cancerFACT-P scoresBaseline to end-of-studySerum PSACAPRA scoreGleason scorePSA levelsPlacebo-controlledMedium-chain triglyceridesPrimary endpointIntermediate riskClinical stageMargin statusSerum testosteroneRandomization armFACT-PRisk strataITT analysisPD45-10 PROSTATE-SPECIFIC MEMBRANE ANTIGEN IMAGING FINDINGS AND SUBSEQUENT CLINICAL MANAGEMENT AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: A RETROSPECTIVE COHORT STUDY
Leapman M, Rabil M, Ghaffar U, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Fallah J, Suzman D, Lerro C, Xu J, Kluetz P, Kunst N, Wang S, Ma X, Gross C, Karnes R. PD45-10 PROSTATE-SPECIFIC MEMBRANE ANTIGEN IMAGING FINDINGS AND SUBSEQUENT CLINICAL MANAGEMENT AMONG PATIENTS WITH BIOCHEMICAL RECURRENT PROSTATE CANCER: A RETROSPECTIVE COHORT STUDY. Journal Of Urology 2024, 211: e971. DOI: 10.1097/01.ju.0001008792.09108.b4.10.Peer-Reviewed Original Research
Clinical Trials
Current Trials
SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 Multi-Institution Randomized Prospective Clinical Trial Evaluating the Impact of Cytoreductive Radical Prostatectomy Combined With Best Systemic Therapy on Oncologic and Quality of Life Outcomes in Men With Newly Diagnosed Metastatic Prostate Cancer
HIC ID2000031290RoleSub InvestigatorPrimary Completion Date10/31/2024Recruiting ParticipantsGenderMaleAge18+ yearsCustomized Ablation of the Prostate With the TULSA Procedure Against Radical Prostatectomy Treatment: a Randomized Controlled Trial for Localized Prostate Cancer (CAPTAIN)
HIC ID2000030487RoleSub InvestigatorPrimary Completion Date12/01/2023Recruiting Participants
Academic Achievements and Community Involvement
honor John N. Forrest Jr. Prize for Mentorship in Student Research
Yale School of Medicine AwardDetails05/19/2022United Stateshonor Best Poster
International AwardEuropean School of Oncology, Conference on Active SurveillanceDetails03/14/2016Italyhonor Merit Award
National AwardConquer Cancer Foundation of the American Society of Clinical OncologyDetails12/01/2015United Stateshonor First Place Essay, History Section
Regional AwardAmerican Urological Association Western SectionDetails08/24/2015United Stateshonor Outstanding Abstract Selected for Oral Presentation
Regional AwardUniversity of California San FranciscoDetails07/01/2015United States
Clinical Care
Overview
Michael S. Leapman, MD, who specializes in prostate, bladder, testicular and kidney cancers, loves his work as a urologic oncologist.
“Every day, I have the ability to make a difference in a patient's life,” says Dr. Leapman. “It's a tremendous honor and responsibility, and it's very rewarding.”
A member of Yale Cancer Center, he sees patients at Smilow Cancer Hospital and the West Haven Veteran’s Administration. An assistant professor of urology at Yale School of Medicine, he studies the best treatments for prostate cancer and how gene expression signatures can predict the aggressiveness of this cancer.
“Hearing the emotionally wrought words ‘it’s cancer’ is extremely difficult to navigate,” he says. “So that's one of the issues that we are sensitive to, and continue to strive to improve.”
The patient-physician bond is essential in helping patients with prostate cancer, for example, to choose which kind of treatment is best: surgery, radiation therapy or active surveillance, an ongoing monitoring of what can be a slow-progressing disease.
“It really is a very special relationship between a urologist and a patient. I have found that the team at Yale is 100 percent invested in the outcomes of our patients, and we stand out by seeking to understand their concerns, goals by being there for them every step of the way.”
Clinical Specialties
Fact Sheets
Prostate Cancer
Learn More on Yale MedicineHormonal Therapy for Cancer
Learn More on Yale MedicineUrologic Cancers
Learn More on Yale MedicineTransitional Cell Cancer of the Renal Pelvis and Ureter
Learn More on Yale Medicine
Board Certifications
Urology
- Certification Organization
- AB of Urology
- Original Certification Date
- 2018
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Urology
PO Box 208058
New Haven, CT 06520-8058
United States
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