Cancer Signaling Networks Recent Publications

2023

TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.Gallego-Paez LM, Edwards WJS, Chanduri M, Guo Y, Koorman T, Lee CY, Grexa N, Derksen P, Yan J, Schwartz MA, Mauer J, Goult BT. J Cell Biol. 2023 May 1; 2023 Mar 6. PMID: 36880935.
SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection.Greaney AM, Raredon MSB, Kochugaeva MP, Niklason LE, Levchenko A. iScience. 2023 Mar 17; 2023 Feb 10. PMID: 36788793.
LIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition.Malvi P, Reddy DS, Kumar R, Chava S, Burela S, Parajuli K, Zhang X, Wajapeyee N. Oncogene. 2023 Mar 16; 2023 Mar 16. PMID: 36922679.
Spatial epigenome-transcriptome co-profiling of mammalian tissues.Zhang D, Deng Y, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G, Fan R. Nature. 2023 Mar 15; 2023 Mar 15. PMID: 36922587.
Tissue Age Affects Antigenicity and Scoring for the 22C3 Immunohistochemistry Companion Diagnostic Test.Fernandez AI, Gaule P, Rimm DL. Mod Pathol. 2023 Mar 14; 2023 Mar 14. PMID: 36925070.
Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion.Chen AT, Xiao Y, Tang X, Baqri M, Gao X, Reschke M, Sheu WC, Long G, Zhou Y, Deng G, Zhang S, Deng Y, Bai Z, Kim D, Huttner A, Kunes R, Günel M, Moliterno J, Saltzman WM, Fan R, Zhou J. Neuro Oncol. 2023 Mar 14. PMID: 35901838.
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease.Vidyadhara DJ, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam TT, Sames D, Greene LE, Sulzer DL, Chandra SS. Cell Rep. 2023 Mar 13; 2023 Mar 13. PMID: 36920906.
Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations.Grant MJ, Aredo JV, Starrett JH, Stockhammer P, van Alderwerelt van Rosenburgh IK, Wurtz A, Piper-Valillo AJ, Piotrowska Z, Falcon C, Yu HA, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li FY, Neal J, Lemmon MA, Walther Z, Politi K, Goldberg SB. Clin Cancer Res. 2023 Mar 13; 2023 Mar 13. PMID: 36913537.
Spatial characterization and quantification of CD40 expression across cancer types.Bates KM, Vathiotis I, MacNeil T, Ahmed FS, Aung TN, Katlinskaya Y, Bhattacharya S, Psyrri A, Yea S, Parkes A, Sadraei NH, Roychoudhury S, Rimm DL, Gavrielatou N. BMC Cancer. 2023 Mar 9; 2023 Mar 9. PMID: 36894898.
Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo.May D, Yun S, Gonzalez DG, Park S, Chen Y, Lathrop E, Cai B, Xin T, Zhao H, Wang S, Gonzalez LE, Cockburn K, Greco V. Elife. 2023 Mar 7; 2023 Mar 7. PMID: 36880644.
Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens.Fang Z, Monteiro VS, Renauer PA, Shang X, Suzuki K, Ling X, Bai M, Xiang Y, Levchenko A, Booth CJ, Lucas C, Chen S. Cell Res. 2023 Mar 6; 2023 Mar 6. PMID: 36879038.
Solving a molecular cryptogram for the human fingerprint.Myung P, Ito M. Cell. 2023 Mar 2. PMID: 36868211.
Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors.Kluger H, Barrett JC, Gainor JF, Hamid O, Hurwitz M, LaVallee T, Moss RA, Zappasodi R, Sullivan RJ, Tawbi H, Sharon E. J Immunother Cancer. 2023 Mar. PMID: 36918224.
Plasma renalase levels are associated with the development of acute pancreatitis.Wang M, Weiss FU, Guo X, Kolodecik T, Bewersdorf JP, Laine L, Lerch MM, Desir G, Gorelick FS. Pancreatology. 2023 Mar; 2023 Jan 3. PMID: 36697349.
DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ.Pramio DT, Vieceli FM, Varella-Branco E, Goes CP, Kobayashi GS, da Silva Pelegrina DV, de Moraes BC, El Allam A, De Kumar B, Jara G, Farfel JM, Bennett DA, Kundu S, Viapiano MS, Reis EM, de Oliveira PSL, Dos Santos E Passos-Bueno MR, Rothlin CV, Ghosh S, Schechtman D. Biochim Biophys Acta Gene Regul Mech. 2023 Mar; 2023 Jan 20. PMID: 36682583.
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Diabetologia. 2023 Mar; 2022 Dec 1. PMID: 36456864.
Endothelial Cell-Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs).Min W, Zhou JH. Cold Spring Harb Perspect Med. 2023 Mar 1; 2023 Mar 1. PMID: 35667709.
First Organoid Intelligence (OI) workshop to form an OI community.Morales Pantoja IE, Smirnova L, Muotri AR, Wahlin KJ, Kahn J, Boyd JL, Gracias DH, Harris TD, Cohen-Karni T, Caffo BS, Szalay AS, Han F, Zack DJ, Etienne-Cummings R, Akwaboah A, Romero JC, Alam El Din DM, Plotkin JD, Paulhamus BL, Johnson EC, Gilbert F, Curley JL, Cappiello B, Schwamborn JC, Hill EJ, Roach P, Tornero D, Krall C, Parri R, Sillé F, Levchenko A, Jabbour RE, Kagan BJ, Berlinicke CA, Huang Q, Maertens A, Herrmann K, Tsaioun K, Dastgheyb R, Habela CW, Vogelstein JT, Hartung T. Front Artif Intell. 2023; 2023 Feb 28. PMID: 36925616.
High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq.Liu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Nam J, Gao F, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft JE, Hafler D, Fan R. Nat Biotechnol. 2023 Feb 23; 2023 Feb 23. PMID: 36823353.
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis.Ahangari F, Price NL, Malik S, Chioccioli M, Bärnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosmos C Jr, Rose KS, McDonough JE, Aurelien NR, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba Nunez JA, Sharma L, Ryu C, Dela Cruz CS, Liu X, Prasse A, Rosas I, Bahal R, Fernández-Hernando C, Kaminski N. JCI Insight. 2023 Feb 22; 2023 Feb 22. PMID: 36626225.
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. Br J Cancer. 2023 Feb 21; 2023 Feb 21. PMID: 36810913.
CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis.Dunbar A, Kim D, Lu M, Farina M, Bowman RL, Yang JL, Park YC, Karzai A, Xiao W, Zaroogian Z, O'Connor K, Mowla S, Gobbo F, Verachi P, Martelli F, Sarli G, Xia L, Elmansy N, Kleppe M, Chen Z, Xiao Y, McGovern EM, Snyder J, Krishnan A, Hill CE, Cordner KB, Zouak A, Salama ME, Yohai J, Tucker E, Chen JJ, Zhou J, McConnell TS, Migliaccio AR, Koche RP, Rampal RK, Fan R, Levine RL, Hoffman R. Blood. 2023 Feb 17; 2023 Feb 17. PMID: 36800567.
Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation.Athonvarangkul D, Wysolmerski JJ. Front Physiol. 2023; 2023 Feb 16. PMID: 36875035.
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus.Robert SM, Reeves BC, Kiziltug E, Duy PQ, Karimy JK, Mansuri MS, Marlier A, Allington G, Greenberg ABW, DeSpenza T Jr, Singh AK, Zeng X, Mekbib KY, Kundishora AJ, Nelson-Williams C, Hao LT, Zhang J, Lam TT, Wilson R, Butler WE, Diluna ML, Feinberg P, Schafer DP, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick DD Jr, Schiff SJ, Carter BS, Gunel M, Simard JM, Lifton RP, Alper SL, Delpire E, Kahle KT. Cell. 2023 Feb 16. PMID: 36803604.
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability.An SJ, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J. Proc Natl Acad Sci U S A. 2023 Feb 14; 2023 Feb 6. PMID: 36745784.
Multi-Institutional Study of Pathologist Reading of the Programmed Cell Death Ligand-1 Combined Positive Score Immunohistochemistry Assay for Gastric or Gastroesophageal Junction Cancer.Fernandez AI, Robbins CJ, Gaule P, Agostini-Vulaj D, Anders RA, Bellizi A, Chen W, Chen ZE, Gopal P, Zhao L, Lisovsky M, Liu X, Shia J, Wang H, Yang Z, McCann L, Chan YG, Weidler J, Bates M, Zhang X, Rimm DL. Mod Pathol. 2023 Feb 13; 2023 Feb 13. PMID: 36889057.
It's Not Just for Pain: A New Metabolic Function of Aspirin.Perry RJ. Endocrinology. 2023 Feb 11. PMID: 36809391.
Epigenetics as a mediator of plasticity in cancer.Feinberg AP, Levchenko A. Science. 2023 Feb 10; 2023 Feb 10. PMID: 36758093.
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy.Wang Y, Malik S, Suh HW, Xiao Y, Deng Y, Fan R, Huttner A, Bindra RS, Singh V, Saltzman WM, Bahal R. Sci Adv. 2023 Feb 10; 2023 Feb 8. PMID: 36753549.
Altered Expression of Several Molecular Mediators of Cerebrospinal Fluid Production in Hyp Mice.Kaplan J, Tommasini S, Yao GQ, Zhu M, Nishimura S, Ghazarian S, Louvi A, Insogna K. J Endocr Soc. 2023 Feb 9; 2023 Feb 6. PMID: 36819458.
Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality.Hu Z, Chen PH, Li W, Douglas T, Hines J, Liu Y, Crews CM. J Am Chem Soc. 2023 Feb 8; 2023 Feb 8. PMID: 36753634.
Integrin α(IIb)β(3) intermediates: From molecular dynamics to adhesion assembly.Tong D, Soley N, Kolasangiani R, Schwartz MA, Bidone TC. Biophys J. 2023 Feb 7; 2022 Dec 23. PMID: 36566352.
When aging gets on the way of disposal: Senescent cell suppression of efferocytosis.Rothlin CV, Ghosh S. J Cell Biol. 2023 Feb 6; 2023 Jan 5. PMID: 36602762.
Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II-dependent fashion.Huet-Calderwood C, Rivera-Molina FE, Toomre DK, Calderwood DA. J Cell Biol. 2023 Feb 6; 2022 Nov 23. PMID: 36416725.
The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors.Liu R, Ospanova S, Perry RJ. PLoS One. 2023; 2023 Feb 3. PMID: 36735704.
Reply: novel antidiabetic drugs and the risk for hepatocellular carcinoma. What else to expect from these "wonderful" drug classes?Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2023 Feb 3; 2023 Feb 3. PMID: 36724446.
Post-translational modification and phenotype.Salovska B, Liu Y. Proteomics. 2023 Feb. PMID: 36799530.
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities.Salovska B, Gao E, Müller-Dott S, Li W, Cordon CC, Wang S, Dugourd A, Rosenberger G, Saez-Rodriguez J, Liu Y. Clin Transl Med. 2023 Feb. PMID: 36781298.
Respiratory viruses: New frontiers-a Keystone Symposia report.Cable J, Sun J, Cheon IS, Vaughan AE, Castro IA, Stein SR, López CB, Gostic KM, Openshaw PJM, Ellebedy AH, Wack A, Hutchinson E, Thomas MM, Langlois RA, Lingwood D, Baker SF, Folkins M, Foxman EF, Ward AB, Schwemmle M, Russell AB, Chiu C, Ganti K, Subbarao K, Sheahan TP, Penaloza-MacMaster P, Eddens T. Ann N Y Acad Sci. 2023 Feb 1; 2023 Feb 1. PMID: 36722473.
Oncologic outcomes of neoadjuvant chemotherapy in patients with micropapillary variant urothelial carcinoma of the bladder.Rahman SN, Lokeshwar SD, Syed JS, Javier-Desloges JF, Press BH, Choksi AU, Rajwa P, Pradere B, Ploussard G, Kim JW, Monaghan TF, Renzulli JR, Shariat SF, Leapman MS. Urol Oncol. 2023 Feb; 2022 Dec 5. PMID: 36481253.
Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.Lin NU, Murthy RK, Abramson V, Anders C, Bachelot T, Bedard PL, Borges V, Cameron D, Carey LA, Chien AJ, Curigliano G, DiGiovanna MP, Gelmon K, Hortobagyi G, Hurvitz SA, Krop I, Loi S, Loibl S, Mueller V, Oliveira M, Paplomata E, Pegram M, Slamon D, Zelnak A, Ramos J, Feng W, Winer E. JAMA Oncol. 2023 Feb 1. PMID: 36454580.
Toward a hypothesis-free understanding of how phosphorylation dynamically impacts protein turnover.Li W, Salovska B, Fornasiero EF, Liu Y. Proteomics. 2023 Feb; 2022 Dec 7. PMID: 36422574.
Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984.Kim JW, McKay RR, Radke MR, Zhao S, Taplin ME, Davis NB, Monk P, Appleman LJ, Lara PN Jr, Vaishampayan UN, Zhang J, Paul AK, Bubley G, Van Allen EM, Unlu S, Huang Y, Loda M, Shapiro GI, Glazer PM, LoRusso PM, Ivy SP, Shyr Y, Swisher EM, Petrylak DP. J Clin Oncol. 2023 Feb 1; 2022 Oct 18. PMID: 36256912.
Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions.Kanchanawong P, Calderwood DA. Nat Rev Mol Cell Biol. 2023 Feb; 2022 Sep 27. PMID: 36168065.
Japanese subgroup analysis of EV-301: An open-label, randomized phase 3 study to evaluate enfortumab vedotin versus chemotherapy in subjects with previously treated locally advanced or metastatic urothelial carcinoma.Matsubara N, Yonese J, Kojima T, Azuma H, Matsumoto H, Powles T, Rosenberg JE, Petrylak DP, Matsangou M, Wu C, Campbell M, Yamashiro M. Cancer Med. 2023 Feb; 2022 Sep 2. PMID: 36052536.
Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling.Canfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson BM, Sun J, Price NL, Fernández-Fuertes M, Fowler JW, Gómez-Coronado D, Sessa WC, Giannarelli C, Schneider RJ, Tellides G, McDonald JG, Fernández-Hernando C, Suárez Y. Circulation. 2023 Jan 31; 2022 Nov 23. PMID: 36416142.
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa.Mercau ME, Akalu YT, Mazzoni F, Gyimesi G, Alberto EJ, Kong Y, Hafler BP, Finnemann SC, Rothlin CV, Ghosh S. Sci Adv. 2023 Jan 20; 2023 Jan 20. PMID: 36662852.
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?Shillingford SR, Bennett AM. Annu Rev Pharmacol Toxicol. 2023 Jan 20. PMID: 36662585.
FORT-1: Phase II/III Study of Rogaratinib Versus Chemotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Selected Based on FGFR1/3 mRNA Expression.Sternberg CN, Petrylak DP, Bellmunt J, Nishiyama H, Necchi A, Gurney H, Lee JL, van der Heijden MS, Rosenbaum E, Penel N, Pang ST, Li JR, García Del Muro X, Joly F, Pápai Z, Bao W, Ellinghaus P, Lu C, Sierecki M, Coppieters S, Nakajima K, Ishida TC, Quinn DI. J Clin Oncol. 2023 Jan 20; 2022 Oct 14. PMID: 36240478.
Ectopic RING activity at the ER membrane differentially impacts ERAD protein quality control pathways.Mehrtash AB, Hochstrasser M. J Biol Chem. 2023 Jan 19; 2023 Jan 19. PMID: 36682496.
Outcomes With Combination Pembrolizumab and Axitinib in Second and Further Line Treatment of Metastatic Renal Cell Carcinoma.Dizman N, Austin M, Considine B, Jessel S, Schoenfeld D, Merl MY, Hurwitz M, Sznol M, Kluger H. Clin Genitourin Cancer. 2023 Jan 12; 2023 Jan 12. PMID: 36681606.
Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors.Shi G, Song C, Torres Robles J, Salichos L, Lou HJ, Lam TT, Gerstein M, Turk BE. Sci Signal. 2023 Jan 10; 2023 Jan 10. PMID: 36626580.
Multi-institutional Assessment of Pathologist Scoring HER2 Immunohistochemistry.Robbins CJ, Fernandez AI, Han G, Wong S, Harigopal M, Podoll M, Singh K, Ly A, Kuba MG, Wen H, Sanders MA, Brock J, Wei S, Fadare O, Hanley K, Jorns J, Snir OL, Yoon E, Rabe K, Soong TR, Reisenbichler ES, Rimm DL. Mod Pathol. 2023 Jan. PMID: 36788069.
The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques.Kabir I, Zhang X, Dave JM, Chakraborty R, Qu R, Chandran RR, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin KA, Fernández-Hernando C, Greif DM. Nat Aging. 2023 Jan; 2023 Jan 9. PMID: 36743663.
Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis.Huet-Calderwood C, Rivera-Molina F, Toomre D, Calderwood DA. Methods Mol Biol. 2023. PMID: 36653699.
An atlas of substrate specificities for the human serine/threonine kinome.Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Nature. 2023 Jan; 2023 Jan 11. PMID: 36631611.
Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study.Cheemarla NR, Hanron A, Fauver JR, Bishai J, Watkins TA, Brito AF, Zhao D, Alpert T, Vogels CBF, Ko AI, Schulz WL, Landry ML, Grubaugh ND, van Dijk D, Foxman EF. Lancet Microbe. 2023 Jan. PMID: 36586415.
The Pathologists' Conundrum.Rimm DL, Dacic S, Schnitt SJ. Arch Pathol Lab Med. 2023 Jan 1. PMID: 36577091.
Primary care institutional characteristics associated with hypertension awareness, treatment, and control in the China PEACE-Million Persons Project and primary health-care survey: a cross-sectional study.Zhou T, Wang Y, Zhang H, Wu C, Tian N, Cui J, Bai X, Yang Y, Zhang X, Lu Y, Spatz ES, Ross JS, Krumholz HM, Lu J, Li X, Hu S. Lancet Glob Health. 2023 Jan. PMID: 36521957.
An Algorithm as a Biomarker for Response to Immune Checkpoint Inhibitor Therapy.Rimm DL. JAMA Oncol. 2023 Jan 1. PMID: 36394848.
Effect of Androgen-Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients.Ünlü S, Shin JJ, Par-Young J, Simonov M, Vinetz J, Petrylak DP, Kang I, Kim JW. Cancer Invest. 2023 Jan; 2022 Nov 17. PMID: 36373994.
Ketones: the double-edged sword of SGLT2 inhibitors?Lupsa BC, Kibbey RG, Inzucchi SE. Diabetologia. 2023 Jan; 2022 Oct 18. PMID: 36255460.
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial.Hricik DE, Armstrong B, Alhamad T, Brennan DC, Bromberg JS, Bunnapradist S, Chandran S, Fairchild RL, Foley DP, Formica R, Gibson IW, Kesler K, Kim SJ, Mannon RB, Menon MC, Newell KA, Nickerson P, Odim J, Poggio ED, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger PS. J Am Soc Nephrol. 2023 Jan 1; 2022 Oct 4. PMID: 36195441.
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.Codella R, Alves TC, Befroy DE, Choi CS, Luzi L, Rothman DL, Kibbey RG, Shulman GI. FEBS Lett. 2023 Jan; 2022 Sep 27. PMID: 36114012.
Enfortumab Vedotin Plus Pembrolizumab in Previously Untreated Advanced Urothelial Cancer.Hoimes CJ, Flaig TW, Milowsky MI, Friedlander TW, Bilen MA, Gupta S, Srinivas S, Merchan JR, McKay RR, Petrylak DP, Sasse C, Moreno BH, Yu Y, Carret AS, Rosenberg JE. J Clin Oncol. 2023 Jan 1; 2022 Aug 30. PMID: 36041086.
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis.Timberlake AT, Kiziltug E, Jin SC, Nelson-Williams C, Loring E, Allocco A, Marlier A, Banka S, Stuart H, Passos-Buenos MR, Rosa R, Rogatto SR, Tonne E, Stiegler AL, Boggon TJ, Alperovich M, Steinbacher D, Staffenberg DA, Flores RL, Persing JA, Kahle KT, Lifton RP. Hum Genet. 2023 Jan; 2022 Aug 23. PMID: 35997807.

2022

UCP2-dependent redox sensing in POMC neurons regulates feeding.Yoon NA, Jin S, Kim JD, Liu ZW, Sun Q, Cardone R, Kibbey R, Diano S. Cell Rep. 2022 Dec 27. PMID: 36577374.
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.Kshitiz, Afzal J, Suhail Y, Chang H, Hubbi ME, Hamidzadeh A, Goyal R, Liu Y, Sun P, Nicoli S, Dang CV, Levchenko A. Cell Syst. 2022 Dec 21; 2022 Dec 2. PMID: 36462504.
Langerhans cells are essential components of the angiogenic niche during murine skin repair.Wasko R, Bridges K, Pannone R, Sidhu I, Xing Y, Naik S, Miller-Jensen K, Horsley V. Dev Cell. 2022 Dec 19; 2022 Dec 8. PMID: 36493773.
Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia.Weber TJ, Imel EA, Carpenter TO, Peacock M, Portale AA, Hetzer J, Merritt JL, Insogna K. J Clin Endocrinol Metab. 2022 Dec 17. PMID: 36072994.
Baseline gene expression profiling determines long-term benefit to programmed cell death protein 1 axis blockade.Vathiotis IA, Salichos L, Martinez-Morilla S, Gavrielatou N, Aung TN, Shafi S, Wong PF, Jessel S, Kluger HM, Syrigos KN, Warren S, Gerstein M, Rimm DL. NPJ Precis Oncol. 2022 Dec 15; 2022 Dec 15. PMID: 36522538.
Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during Infection.Adcox HE, Berk JM, Hochstrasser M, Carlyon JA. Infect Immun. 2022 Dec 15; 2022 Nov 14. PMID: 36374099.
Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure.Qu R, Kluger Y, Yang J, Zhao J, Hafler DA, Krause DS, Bersenev A, Bosenberg M, Hurwitz M, Lucca L, Kluger HM. Mol Cancer. 2022 Dec 14; 2022 Dec 14. PMID: 36514045.
Susan L. Solomon (1951-2022): Advocate, Innovator, Catalyst.Fossati V, Greco V, Arlotta P, Aiyar RS. Stem Cell Reports. 2022 Dec 13. PMID: 36516737.
Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants.Krimmer SG, Schlessinger J. Proc Natl Acad Sci U S A. 2022 Dec 13; 2022 Dec 7. PMID: 36475945.
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.Adua SJ, Arnal-Estapé A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert AE, Melnick MA, Hu B, Politi K, Chiang V, Colclough N, Goodwin RJA, Cross D, Smith P, Nguyen DX. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509758.
Regulation of bone homeostasis by MERTK and TYRO3.Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu TV, Beitzen-Heineke A, Vargas-Delgado ME, Pantel K, Bokemeyer C, Bhamidipati S, Darwish IS, Masuda E, Burstyn-Cohen T, Alberto EJ, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509738.
A path to translation: How 3D patient tumor avatars enable next generation precision oncology.Barroso M, Chheda MG, Clevers H, Elez E, Kaochar S, Kopetz SE, Li XN, Meric-Bernstam F, Meyer CA, Mou H, Naegle KM, Pera MF, Perova Z, Politi KA, Raphael BJ, Robson P, Sears RC, Tabernero J, Tuveson DA, Welm AL, Welm BE, Willey CD, Salnikow K, Chuang JH, Shen X. Cancer Cell. 2022 Dec 12; 2022 Oct 20. PMID: 36270276.
Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.Zhang H, Li B, Huang Q, López-Giráldez F, Tanaka Y, Lin Q, Mehta S, Wang G, Graham M, Liu X, Park IH, Eichmann A, Min W, Zhou JH. Nat Commun. 2022 Dec 10; 2022 Dec 10. PMID: 36496409.
Reindeer light the way to scarless wound healing.Caves E, Horsley V. Cell. 2022 Dec 8. PMID: 36493748.
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Eur J Med Chem. 2022 Dec 5; 2022 Sep 2. PMID: 36116232.
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity.Zhang X, Halberstam AA, Zhu W, Leitner BP, Thakral D, Bosenberg MW, Perry RJ. Cancer Metab. 2022 Dec 1; 2022 Dec 1. PMID: 36457136.
The origins of skin diversity: lessons from dermal fibroblasts.Myung P, Andl T, Atit R. Development. 2022 Dec 1; 2022 Nov 29. PMID: 36444877.
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP.Stiegler AL, Vish KJ, Boggon TJ. Structure. 2022 Dec 1; 2022 Nov 22. PMID: 36417908.
Correction to: Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore: a modeling study.Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Lindsey PJ, Westra RL. J Biol Phys. 2022 Dec. PMID: 36370323.
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.Cockburn K, Annusver K, Gonzalez DG, Ganesan S, May DP, Mesa KR, Kawaguchi K, Kasper M, Greco V. Nat Cell Biol. 2022 Dec; 2022 Nov 10. PMID: 36357619.
A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM. J Biol Chem. 2022 Dec; 2022 Oct 19. PMID: 36272649.
Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells.Wang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Chem Biol Interact. 2022 Dec 1; 2022 Sep 23. PMID: 36162455.
Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)P(3) and actomyosin.Li X, Shim S, Hardin KR, Vanaja KG, Song H, Levchenko A, Ming GL, Zheng JQ. Mol Cell Neurosci. 2022 Dec; 2022 Aug 31. PMID: 36055521.
YES1 Is a Druggable Oncogenic Target in SCLC.Redin E, Garrido-Martin EM, Valencia K, Redrado M, Solorzano JL, Carias R, Echepare M, Exposito F, Serrano D, Ferrer I, Nunez-Buiza A, Garmendia I, García-Pedrero JM, Gurpide A, Paz-Ares L, Politi K, Montuenga LM, Calvo A. J Thorac Oncol. 2022 Dec; 2022 Aug 18. PMID: 35988891.
Segmental basaloid follicular hamartomas derive from a post-zygotic SMO p.L412F pathogenic variant and express hair follicle development-related proteins in a pattern that distinguish them from basal cell carcinomas.Atzmony L, Ugwu N, Bercovitch LG, Robinson-Bostom L, Ko CJ, Myung P, Choate KA. Am J Med Genet A. 2022 Dec; 2022 Aug 16. PMID: 35972041.
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis.An SJ, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D. Proc Natl Acad Sci U S A. 2022 Nov 29; 2022 Nov 23. PMID: 36417441.
3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications.Dell AC, Wagner G, Own J, Geibel JP. Pharmaceutics. 2022 Nov 24; 2022 Nov 24. PMID: 36559090.
Double knockin mice show NF-κB trajectories in immune signaling and aging.Rahman SMT, Aqdas M, Martin EW, Tomassoni Ardori F, Songkiatisak P, Oh KS, Uderhardt S, Yun S, Claybourne QC, McDevitt RA, Greco V, Germain RN, Tessarollo L, Sung MH. Cell Rep. 2022 Nov 22. PMID: 36417863.
Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins.Tsai PL, Cameron CJF, Forni MF, Wasko RR, Naughton BS, Horsley V, Gerstein MB, Schlieker C. Cell Rep. 2022 Nov 22. PMID: 36417855.
Ki67 as a Companion Diagnostic: Good or Bad News?Dowsett M, Nielsen TO, Rimm DL, Hayes DF. J Clin Oncol. 2022 Nov 20; 2022 Jul 11. PMID: 35816627.
Rho family GTPase signaling through type II p21-activated kinases.Chetty AK, Ha BH, Boggon TJ. Cell Mol Life Sci. 2022 Nov 19; 2022 Nov 19. PMID: 36401658.
Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets.Mehrtash AB, Hochstrasser M. iScience. 2022 Nov 18; 2022 Oct 13. PMID: 36325070.
Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4).Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ. Commun Biol. 2022 Nov 17; 2022 Nov 17. PMID: 36385162.
Integrin Conformational Dynamics and Mechanotransduction.Kolasangiani R, Bidone TC, Schwartz MA. Cells. 2022 Nov 12; 2022 Nov 12. PMID: 36429013.