Cancer Signaling Networks Recent Publications

• Rapid and sustained improvements in itch and quality of life with upadacitinib plus topical corticosteroids in adults and adolescents with atopic dermatitis: 52-week outcomes from the phase 3 AD Up study.Magnolo N, Cameron MC, Shahriari M, Geng B, Calimlim BM, Teixeira H, Hu X, Yang Y, Liu Y, Zhang S, Sancho Sanchez C, Altman K, Langley RG. J Dermatolog Treat. 2024 Dec; 2024 May 2. PMID: 38697950.
• Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes.Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. J Cell Biol. 2024 Nov 4; 2024 Aug 28. PMID: 39196069.
• A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.Johnson B, Iuliano M, Lam TT, Biederer T, De Camilli PV. J Cell Biol. 2024 Nov 4; 2024 Aug 19. PMID: 39158698.
• Chitinase 3-like-1 (CHI3L1) in the pathogenesis of epidermal growth factor receptor mutant non-small cell lung cancer.Kamle S, Ma B, Schor G, Bailey M, Pham B, Cho I, Khan H, Azzoli C, Hofstetter M, Sadanaga T, Herbst R, Politi K, Lee CG, Elias JA. Transl Oncol. 2024 Nov; 2024 Aug 22. PMID: 39178575.
• TROPHY-U-01 Cohort 2: A Phase II Study of Sacituzumab Govitecan in Cisplatin-Ineligible Patients With Metastatic Urothelial Cancer Progressing After Previous Checkpoint Inhibitor Therapy.Petrylak DP, Tagawa ST, Jain RK, Bupathi M, Balar A, Kalebasty AR, George S, Palmbos P, Nordquist L, Davis N, Ramamurthy C, Sternberg CN, Loriot Y, Agarwal N, Park C, Tonelli J, Vance M, Zhou H, Grivas P. J Clin Oncol. 2024 Oct 10; 2024 Aug 26. PMID: 39186707.
• DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force.Chung M, Zhou K, Powell JT, Lin C, Schwartz MA. ACS Nano. 2024 Oct 8; 2024 Sep 29. PMID: 39344156.
• Regulation and signaling of the LIM domain kinases.Casanova-Sepúlveda G, Boggon TJ. Bioessays. 2024 Oct 3; 2024 Oct 3. PMID: 39361252.
• Feeding the wrath with myelin.Ghosh S, Rothlin CV. Trends Immunol. 2024 Oct; 2024 Sep 27. PMID: 39341708.
• Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
• Trends in breast cancer specific death by clinical stage at diagnoses between 2000-2017.Marczyk M, Kahn A, Silber A, Rosenblit M, Digiovanna MP, Lustberg M, Pusztai L. J Natl Cancer Inst. 2024 Sep 30; 2024 Sep 30. PMID: 39348186.
• Deletion of miR-33, a regulator of the ABCA1-APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice.Tate M, Wijeratne HRS, Kim B, Philtjens S, You Y, Lee DH, Gutierrez DA, Sharify D, Wells M, Perez-Cardelo M, Doud EH, Fernandez-Hernando C, Lasagna-Reeves C, Mosley AL, Kim J. Alzheimers Dement. 2024 Sep 30; 2024 Sep 30. PMID: 39345217.
• A Fluorescence-Based Assay for Measuring Polyamine Biosynthesis Aminopropyl Transferase-Mediated Catalysis.Singh P, Choi JY, Wang W, Lam T, Lechner P, Vanderwal CD, Pou S, Nilsen A, Ben Mamoun C. J Biol Chem. 2024 Sep 27; 2024 Sep 27. PMID: 39342998.
• Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues.Bai Z, Zhang D, Gao Y, Tao B, Zhang D, Bao S, Enninful A, Wang Y, Li H, Su G, Tian X, Zhang N, Xiao Y, Liu Y, Gerstein M, Li M, Xing Y, Lu J, Xu ML, Fan R. Cell. 2024 Sep 25; 2024 Sep 25. PMID: 39353436.
• The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8(+) T cells against cancer.Feng B, Bai Z, Zhou X, Zhao Y, Xie YQ, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng MW, Li W, Tao B, Charmoy M, Held W, Melenhorst JJ, Fan R, Guo Y, Tang L. Nature. 2024 Sep 25; 2024 Sep 25. PMID: 39322665.
• Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission.Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R. Nature. 2024 Sep 25; 2024 Sep 25. PMID: 39322664.
• A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK. Curr Biol. 2024 Sep 18; 2024 Sep 18. PMID: 39317195.
• Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing.Leader AE, Rebbeck TR, Oh WK, Patel AV, Winer EP, Bailey LO, Gomella LG, Lumpkins CY, Garraway IP, Aiello LB, Baskin ML, Cheng HH, Cooney KA, Ganzak A, George DJ, Halabi S, Hathaway F, Healy C, Kim JW, Leapman MS, Loeb S, Maxwell KN, McNair C, Morgan TM, Prindeville B, Soule HR, Steward WL, Suttiratana SC, Taplin ME, Yamoah K, Fortune T, Bennett K, Blanding-Godbolt J, Gross L, Giri VN. BMC Public Health. 2024 Sep 18; 2024 Sep 18. PMID: 39289635.
• PTMoreR-enabled cross-species PTM mapping and comparative phosphoproteomics across mammals.Wang S, Di Y, Yang Y, Salovska B, Li W, Hu L, Yin J, Shao W, Zhou D, Cheng J, Liu D, Yang H, Liu Y. Cell Rep Methods. 2024 Sep 16; 2024 Sep 9. PMID: 39255793.
• Development of an Objective Structured Assessment of Technical Skills for Sclerotherapy.Ma MS, Zafar FS, Goldman MP, Munavalli GS, Zimmet SE, Nguyen TH, Mishra V, Cartee TV, Mann M, Hsu JTS, Silapunt S, Weiss RA, Weiss MA, Haq M, Ahmed A, Koza E, Shi VJ, Dave L, Yi M, Kang BY, Cahn B, Bae YSC, Kole LCS, Friedmann DP, Chow ML, Minkis K, Stücker M, Schlick CA, Hoss E, Hu JC, Kibbi N, Saikaly SK, Greywal T, Hooper D, Vashi NA, Boucher A, Ward KHM, Neuhaus IM, Ghareeb E, Luke J, Karen JK, Suggs A, Lucas J, Decker A, Brieva JC, Yoo SS, Suozzi K, Alam M. J Am Acad Dermatol. 2024 Sep 15; 2024 Sep 15. PMID: 39288871.
• Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.Apolo AB, Ballman KV, Sonpavde G, Berg S, Kim WY, Parikh R, Teo MY, Sweis RF, Geynisman DM, Grivas P, Chatta G, Reichert ZR, Kim JW, Bilen MA, McGregor B, Singh P, Tripathi A, Cole S, Simon N, Niglio S, Ley L, Cordes L, Srinivas S, Huang J, Odegaard M, Watt C, Petrylak D, Hoffman-Censits J, Wen Y, Hahn O, Mitchell C, Tan A, Streicher H, Sharon E, Moon H, Woods M, Halabi S, Perez Burbano G, Morris MJ, Rosenberg JE. N Engl J Med. 2024 Sep 15; 2024 Sep 15. PMID: 39282902.
• CALHM2 is a mitochondrial protein import channel that regulates fatty acid metabolism.Jonas E, Mnatsakanyan N, Rivera-Molina F, Robson A, Garfinkel AM, Kumar A, Batter S, Padovano V, Webster K, Cardone R, Berg J, Toomre D, Kibbey R 4th, Caplan M, Khokha M. Res Sq. 2024 Sep 13; 2024 Sep 13. PMID: 39315269.
• Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Tsemperouli M, Cheppali SK, Molina FR, Chetrit D, Landajuela A, Toomre D, Karatekin E. bioRxiv. 2024 Sep 12; 2024 Sep 12. PMID: 39314345.
• Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation.Lallai V, Lam TT, Garcia-Milian R, Chen YC, Fowler JP, Manca L, Piomelli D, Williams K, Nairn AC, Fowler CD. Biomolecules. 2024 Sep 10; 2024 Sep 10. PMID: 39334909.
• Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics.Gordon JM, Phizicky DV, Schärfen L, Brown CL, Arias Escayola D, Kanyo J, Lam TT, Simon MD, Neugebauer KM. Nucleic Acids Res. 2024 Sep 9. PMID: 38943343.
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP. bioRxiv. 2024 Sep 5; 2024 Sep 5. PMID: 39282375.
• Structural insights into the role and targeting of EGFRvIII.Bagchi A, Stayrook SE, Xenaki KT, Starbird CA, Doulkeridou S, El Khoulati R, Roovers RC, Schmitz KR, van Bergen En Henegouwen PMP, Ferguson KM. Structure. 2024 Sep 5; 2024 Jun 21. PMID: 38908376.
• Promoting Collaborative Scholarship During the COVID-19 Pandemic Through an Innovative COVID-19 Data Explorer and Repository at Yale School of Medicine: Development and Usability Study.Victoria-Castro AM, Arora T, Simonov M, Biswas A, Alausa J, Subair L, Gerber B, Nguyen A, Hsiao A, Hintz R, Yamamoto Y, Soufer R, Desir G, Wilson FP, Villanueva M. JMIR Form Res. 2024 Sep 3; 2024 Sep 3. PMID: 39226547.
• Cost trends of metastatic renal cell carcinoma therapy: the impact of oral anticancer agents and immunotherapy.Forman R, Long JB, Westvold SJ, Agnish K, Mcmanus HD, Leapman MS, Hurwitz ME, Spees LP, Wheeler SB, Gross CP, Dinan MA. JNCI Cancer Spectr. 2024 Sep 2. PMID: 39133171.
• High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children.Watkins TA, Green AB, Amat JAR, Cheemarla NR, Hänsel K, Lozano R, Dudgeon SN, Germain G, Landry ML, Schulz WL, Foxman EF. J Exp Med. 2024 Sep 2; 2024 Jul 1. PMID: 38949638.
• Evaluating Treatment Patterns and the Role of Neoadjuvant Chemotherapy in Plasmacytoid Urothelial Carcinoma: Insights from a Combined National and Institutional Series.Rahman S, Kong V, Jalfon M, Hesse D, Kim J, Wright JL, Adeniran A, Humphrey P, Martin DT, Ghali F. Cancers (Basel). 2024 Sep 1; 2024 Sep 1. PMID: 39272908.
• Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis.Joshi D, Coon BG, Chakraborty R, Deng H, Yang Z, Babar MU, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Libreros S, Schwartz MA. Nat Cardiovasc Res. 2024 Sep; 2024 Sep 4. PMID: 39232138.
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness.Stewart KS, Abdusselamoglu MD, Tierney MT, Gola A, Hur YH, Gonzales KAU, Yuan S, Bonny AR, Yang Y, Infarinato NR, Cowley CJ, Levorse JM, Pasolli HA, Ghosh S, Rothlin CV, Fuchs E. Nature. 2024 Sep; 2024 Aug 21. PMID: 39169186.
• Author Correction: Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Nat Med. 2024 Sep. PMID: 39164519.
• Controversy in mechanotransduction - the role of endothelial cell-cell junctions in fluid shear stress sensing.X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y, Schwartz MA. J Cell Sci. 2024 Sep 1; 2024 Sep 9. PMID: 39143856.
• Renalase peptides reduce pancreatitis severity in mice.Kolodecik TR, Guo X, Shugrue CA, Guo X, Desir GV, Wen L, Gorelick F. Am J Physiol Gastrointest Liver Physiol. 2024 Sep 1; 2024 Jul 16. PMID: 39010833.
• Quantitative Measurement of HER2 Expression in Non-Small Cell Lung Cancer With a High-Sensitivity Assay.Liu M, Vathiotis I, Robbins CJ, Chan NNN, Moutafi M, Burela S, Xirou V, Schalper KA, Herbst RS, Syrigos K, Rimm DL. Mod Pathol. 2024 Sep; 2024 Jul 2. PMID: 38964502.
• Deciphering spatial domains from spatial multi-omics with SpatialGlue.Long Y, Ang KS, Sethi R, Liao S, Heng Y, van Olst L, Ye S, Zhong C, Xu H, Zhang D, Kwok I, Husna N, Jian M, Ng LG, Chen A, Gascoigne NRJ, Gate D, Fan R, Xu X, Chen J. Nat Methods. 2024 Sep; 2024 Jun 21. PMID: 38907114.
• The development of hair follicles and nail.Lee SH, Platt S, Lim CH, Ito M, Myung P. Dev Biol. 2024 Sep; 2024 May 15. PMID: 38759942.
• Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease.Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Huang Y, Yang Y, Lin Z, Guo T, Zhao J, Guan Y, Li B, Xie F. Mol Psychiatry. 2024 Sep; 2024 Apr 8. PMID: 38589563.
• BCAM (basal cell adhesion molecule) protein expression in different tumor populations.Burela S, He M, Trontzas IP, Gavrielatou N, Schalper KA, Langermann S, Flies DB, Rimm DL, Aung TN. Discov Oncol. 2024 Aug 29; 2024 Aug 29. PMID: 39207605.
• The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity.Laughlin M, McIndoe R, Adams SH, Araiza R, Ayala JE, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness OP, Perry R, Port D, Qi N, Elias CF, Shulman GI, Wasserman DH, Lloyd KCK. Mamm Genome. 2024 Aug 27; 2024 Aug 27. PMID: 39191872.
• miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression.Fernández-Tussy P, Cardelo MP, Zhang H, Sun J, Price NL, Boutagy NE, Goedeke L, Cadena-Sandoval M, Xirouchaki CE, Brown W, Yang X, Pastor-Rojo O, Haeusler RA, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. JCI Insight. 2024 Aug 27; 2024 Aug 27. PMID: 39190492.
• Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer.Gunasekharan V, Lin HK, Marczyk M, Rios-Hoyo A, Campos GE, Shan NL, Ahmed M, Umlauf S, Gareiss P, Raaisa R, Williams R, Cardone R, Siebel S, Kibbey R, Surovtseva YV, Pusztai L. Breast Cancer Res Treat. 2024 Aug 23; 2024 Aug 23. PMID: 39177932.
• Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz UD, Bai S, Nottoli T, Goult BT, Humphrey JD, Schwartz MA. Sci Adv. 2024 Aug 23; 2024 Aug 21. PMID: 39167642.
• Impact of Prior Chemotherapy on Response to Second-line Pembrolizumab in Urothelial Cancer: Exploratory Analysis of the Phase 3 KEYNOTE-045 Trial.de Wit R, Vaughn DJ, Fradet Y, Fong L, Climent MA, Necchi A, Petrylak DP, Gerritsen WR, Gurney H, Quinn DI, Culine S, Sternberg CN, Bajorin DF, Choueiri TK, Xu J, Imai K, Homet Moreno B, Bellmunt J, Lee JL. Eur Urol. 2024 Aug 21; 2024 Aug 21. PMID: 39174409.
• Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.Malik DM, Rhoades SD, Zhang SL, Sengupta A, Barber A, Haynes P, Arnadottir ES, Pack A, Kibbey RG, Kain P, Sehgal A, Weljie AM. bioRxiv. 2024 Aug 21; 2024 Aug 21. PMID: 37961230.
• Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking.Takagi S, Sancer G, Abuin L, Stupski SD, Roman Arguello J, Prieto-Godino LL, Stern DL, Cruchet S, Álvarez-Ocaña R, Wienecke CFR, van Breugel F, Jeanne JM, Auer TO, Benton R. Nat Commun. 2024 Aug 15; 2024 Aug 15. PMID: 39147786.
• Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma.Aung TN, Warrell J, Martinez-Morilla S, Gavrielatou N, Vathiotis I, Yaghoobi V, Kluger HM, Gerstein M, Rimm DL. Clin Cancer Res. 2024 Aug 15. PMID: 38837895.
• Transcriptional analysis of efferocytosis in mouse skin wounds.Krause W, King D, Horsley V. bioRxiv. 2024 Aug 13; 2024 Aug 13. PMID: 39185146.
• SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling.Xu Y, Zhang H, Chen Y, Pober JS, Zhou M, Zhou JH, Min W. Nat Commun. 2024 Aug 13; 2024 Aug 13. PMID: 39134547.
• The amalgam of naive CD4(+) T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response.Even Z, Meli AP, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky DA, Kong Y, Wang Y, Waizman DA, Rice TA, De Kumar B, Wang X, Palm NW, Craft J, Basu MK, Ghosh S, Rothlin CV. Immunity. 2024 Aug 13; 2024 Aug 2. PMID: 39096910.
• Item Response Theory Quantifies the Relationship Between Improvements in Serum Phosphate and Patient-Reported Outcomes in Adults With X-Linked Hypophosphatemia.Mehta K, Gosselin NH, Insogna K, Barriere O, Quattrocchi E, Hruska MW, Marsteller D. Clin Pharmacol Ther. 2024 Aug 12; 2024 Aug 12. PMID: 39129452.
• Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone.Norton ES, Whaley LA, Jones VK, Brooks MM, Russo MN, Morderer D, Jessen E, Schiapparelli P, Ramos-Fresnedo A, Zarco N, Carrano A, Rossoll W, Asmann YW, Lam TT, Chaichana KL, Anastasiadis PZ, Quiñones-Hinojosa A, Guerrero-Cázares H. Sci Adv. 2024 Aug 9; 2024 Aug 7. PMID: 39110807.
• The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse.Stankewich MC, Peters LL, Morrow JS. Front Neurosci. 2024; 2024 Aug 6. PMID: 39165342.
• TIGIT expression in renal cell carcinoma infiltrating T cells is variable and inversely correlated with PD-1 and LAG3.Perales O, Jilaveanu L, Adeniran A, Su DG, Hurwitz M, Braun DA, Kluger HM, Schoenfeld DA. Cancer Immunol Immunother. 2024 Aug 6; 2024 Aug 6. PMID: 39105820.
• Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.Zaman S, Gorelick FS, Chrobrutskiy A, Chobrutskiy BI, Desir GV, Blanck G. Oncotarget. 2024 Aug 5; 2024 Aug 5. PMID: 39102218.
• Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.Ishchenko Y, Jeng AT, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen KK, Carrizales MG, Vitarelli MJ, Corcoran EE, Greer CA, Myers SA, Koleske AJ. bioRxiv. 2024 Aug 4; 2024 Aug 4. PMID: 39131289.
• A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs.Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, Aman T, Panda A, Kumar S, Li W, Coleman J, Liu Y, Rothman JE, Bhattacharyya M, Gupta K. bioRxiv. 2024 Aug 4; 2024 Aug 4. PMID: 38405833.
• Association Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting.Leapman MS, Ho J, Liu Y, Filson C, Zhao X, Hakansson A, Proudfoot JA, Davicioni E, Martin DT, An Y, Seibert TM, Lin DW, Spratt DE, Cooperberg MR, Sprenkle PC, Ross AE. Eur Urol Oncol. 2024 Aug 3; 2024 Aug 3. PMID: 39098389.
• mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis.Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan VK, Su M, Murray KN, Grutzendler J, Zhou JH. Circ Res. 2024 Aug 2; 2024 Jul 3. PMID: 38957991.
• Sacituzumab Govitecan Demonstrates Efficacy across Tumor Trop-2 Expression Levels in Patients with Advanced Urothelial Cancer.Loriot Y, Balar AV, Petrylak DP, Kalebasty AR, Grivas P, Fléchon A, Jain RK, Swami U, Bupathi M, Barthélémy P, Beuzeboc P, Palmbos P, Kyriakopoulos CE, Pouessel D, Sternberg CN, Tonelli J, Sierecki M, Zavodovskaya M, Elboudwarej E, Diehl L, Jürgensmeier JM, Tagawa ST. Clin Cancer Res. 2024 Aug 1. PMID: 39086310.
• Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. EMBO J. 2024 Aug; 2024 Jun 17. PMID: 38886581.
• Finding Your CAR: The Road Ahead for Engineered T Cells.Chen PH, Raghunandan R, Morrow JS, Katz SG. Am J Pathol. 2024 Aug; 2024 May 1. PMID: 38697513.
• A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.Faniyan TS, Zhang X, Morgan DA, Robles J, Bathina S, Brookes PS, Rahmouni K, Perry RJ, Chhabra KH. Elife. 2024 Jul 31; 2024 Jul 31. PMID: 39082939.
• Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping.Zhang D, Rubio Rodríguez-Kirby LA, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. bioRxiv. 2024 Jul 28; 2024 Jul 28. PMID: 39091821.
• Synergistic interaction between pay-it-forward incentives and recreational drug use on hepatitis B virus and hepatitis C virus testing among men who have sex with men in China.Ai W, Xie Y, Lu H, Ai T, Wu D, Zhang Y, Marley G, Ong J, Tucker JD, Tang W. Sex Transm Infect. 2024 Jul 26; 2024 Jul 26. PMID: 38862237.
• Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.Mühlenbeck H, Tsutsui Y, Lemmon MA, Bender KW, Zipfel C. Elife. 2024 Jul 19; 2024 Jul 19. PMID: 39028038.
• Considerations for viral co-infection studies in human populations.Chin T, Foxman EF, Watkins TA, Lipsitch M. mBio. 2024 Jul 17; 2024 Jun 7. PMID: 38847531.
• Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.Edman NI, Phal A, Redler RL, Schlichthaerle T, Srivatsan SR, Ehnes DD, Etemadi A, An SJ, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry CE, Schweppe DK, Freedman BS, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Cell. 2024 Jul 11; 2024 Jun 10. PMID: 38861993.
• A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling.Deng H, Zhang J, Wang Y, Joshi D, Pi X, De Val S, Schwartz MA. Nat Cardiovasc Res. 2024 Jul; 2024 Jul 8. PMID: 39196179.
• Deficits in brain glucose transport among younger adults with obesity.Gunawan F, Matson BC, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez-Rangel E, DeAguiar RB, Behar KL, Rothman DL, Mason GF, Hwang JJ. Obesity (Silver Spring). 2024 Jul; 2024 May 19. PMID: 38764181.
• CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.Pal SK, Tran B, Haanen JBAG, Hurwitz ME, Sacher A, Tannir NM, Budde LE, Harrison SJ, Klobuch S, Patel SS, Meza L, Dequeant ML, Ma A, He QA, Williams LM, Keegan A, Gurary EB, Dar H, Karnik S, Guo C, Heath H, Yuen RR, Morrow PK, Agarwal N, Srour SA. Cancer Discov. 2024 Jul 1. PMID: 38583184.
• Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis.Zhu M, Zeiss C, Hamrick MW, Weinstein RS, Sun BH, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Bone. 2024 Jul; 2024 Mar 27. PMID: 38552893.
• TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease.Pellowe AS, Wu MJ, Kang TY, Chung TD, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez AL. Am J Pathol. 2024 Jul; 2024 Mar 26. PMID: 38548268.
• Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue.Farzad N, Enninful A, Bao S, Zhang D, Deng Y, Fan R. Nat Protoc. 2024 Jun 28; 2024 Jun 28. PMID: 38943021.
• MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway.Dorry S, Perla S, Bennett AM. bioRxiv. 2024 Jun 27; 2024 Jun 27. PMID: 38979264.
• Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
• Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.Yao X, Chen R, Chen H, Koleske A, Xiao X. Behav Brain Res. 2024 Jun 25; 2024 Apr 30. PMID: 38697301.
• Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH.Schnittman SR, Talathi R, Wilks MQ, Hedgire S, Lu MT, Fourman LT, Alagpulinsa DA, Stockman SL, White KS, Wallis ZK, Autissier P, Stanley TL, Lee H, Honigberg MC, El-Fakhri G, Williams KC, Zanni MV, Grinspoon SK, Toribio M. AIDS. 2024 Jun 21; 2024 Jun 21. PMID: 38905489.
• A causal link between autoantibodies and neurological symptoms in long COVID.Santos Guedes de Sa K, Silva J, Bayarri-Olmos R, Brinda R, Alec Rath Constable R, Colom Diaz PA, Kwon DI, Rodrigues G, Wenxue L, Baker C, Bhattacharjee B, Wood J, Tabacof L, Liu Y, Putrino D, Horvath TL, Iwasaki A. medRxiv. 2024 Jun 19; 2024 Jun 19. PMID: 38947091.
• Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment.Martinez-Terroba E, Plasek-Hegde LM, Chiotakakos I, Li V, de Miguel FJ, Robles-Oteiza C, Tyagi A, Politi K, Zamudio JR, Dimitrova N. Sci Immunol. 2024 Jun 14; 2024 Jun 14. PMID: 38875320.
• Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling.Ohashi Y, Protack CD, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider EB, Long X, Perry RJ, Dardik A. Sci Rep. 2024 Jun 10; 2024 Jun 10. PMID: 38858395.
• High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC).Moutafi MK, Bates KM, Aung TN, Milian RG, Xirou V, Vathiotis IA, Gavrielatou N, Angelakis A, Schalper KA, Salichos L, Rimm DL. J Immunother Cancer. 2024 Jun 10; 2024 Jun 10. PMID: 38857914.
• A DNA-based molecular clamp for probing protein interactions and structure under force.Chung M, Zhou K, Powell J, Lin C, Schwartz MA. bioRxiv. 2024 Jun 6; 2024 Jun 6. PMID: 38895381.
• Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage.Leapman MS, Ho J, Liu Y, Filson CP, Zhao X, Hakansson A, Proudfoot JA, Davicioni E, Martin DT, An Y, Seibert TM, Lin DW, Spratt DE, Cooperberg MR, Ross AE, Sprenkle PC. JAMA Netw Open. 2024 Jun 3; 2024 Jun 3. PMID: 38874922.
• SenNet recommendations for detecting senescent cells in different tissues.Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. Nat Rev Mol Cell Biol. 2024 Jun 3; 2024 Jun 3. PMID: 38831121.
• Development of (225)Ac-doped biocompatible nanoparticles for targeted alpha therapy.Toro-González M, Akingbesote N, Bible A, Pal D, Sanders B, Ivanov AS, Jansone-Popova S, Popovs I, Benny P, Perry R, Davern S. J Nanobiotechnology. 2024 Jun 2; 2024 Jun 2. PMID: 38825717.
• Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!Merrins MJ, Kibbey RG. Diabetes. 2024 Jun 1. PMID: 38768366.
• Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Xin T, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S, Greco V. Nat Cell Biol. 2024 Jun; 2024 Apr 30. PMID: 38689013.
• Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment.Wang J, Huang Q, He K, Li J, Guo T, Yang Y, Lin Z, Li S, Vanderlinden G, Huang Y, Van Laere K, Guan Y, Guo Q, Ni R, Li B, Xie F. Alzheimers Dement. 2024 Jun; 2024 Apr 18. PMID: 38634334.
• Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment.Butt A, Christian J, Kress A, Lu BY, Hurwitz ME, Goldberg SB, Podoltsev NA, Gilkes L, Lee AI. J Cancer Educ. 2024 Jun; 2024 Mar 2. PMID: 38430454.
• Health-related Quality of Life in Patients with Previously Treated Advanced Urothelial Carcinoma from EV-301: A Phase 3 Trial of Enfortumab Vedotin Versus Chemotherapy.Rosenberg JE, Mamtani R, Sonpavde GP, Loriot Y, Duran I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Sridhar SS, Pappot H, Gurney H, Bedke J, van der Heijden MS, Galli L, Keam B, Masumori N, Meran J, O'Donnell PH, Park SH, Grande E, Sengeløv L, Uemura H, Skaltsa K, Campbell M, Matsangou M, Wu C, Hepp Z, McKay C, Powles T, Petrylak DP. Eur Urol. 2024 Jun; 2024 Feb 28. PMID: 38418343.
• Author Correction: Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients.Uhlig J, Uhlig A, Deshpande H, Ströbel P, Trojan L, Lotz J, Hurwitz M, Hafez O, Humphrey P, Grünwald V, Kim HS. Sci Rep. 2024 May 24; 2024 May 24. PMID: 38789511.
• The Evolution of Mouse Models of Cancer: Past, Present, and Future.Abate-Shen C, Politi K. Cold Spring Harb Perspect Med. 2024 May 21; 2024 May 21. PMID: 38772706.
• Viral Interference During Influenza A-SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir.Cheemarla NR, Watkins TA, Mihaylova VT, Foxman EF. J Infect Dis. 2024 May 15. PMID: 37722683.
• Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells.Zhang H, Read A, Cataisson C, Yang HH, Lee WC, Turk BE, Yuspa SH, Luo J. Sci Signal. 2024 May 14; 2024 May 14. PMID: 38743809.
• In the Eyes of the Beholder-New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK.Ghosh S, Finnemann SC, Vollrath D, Rothlin CV. Int J Mol Sci. 2024 May 13; 2024 May 13. PMID: 38791338.
• Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis.Rosenberger G, Li W, Turunen M, He J, Subramaniam PS, Pampou S, Griffin AT, Karan C, Kerwin P, Murray D, Honig B, Liu Y, Califano A. Nat Commun. 2024 May 9; 2024 May 9. PMID: 38724493.
• Fibroblast expression of transmembrane protein smoothened governs microenvironment characteristics after acute kidney injury.Gui Y, Fu H, Palanza Z, Tao J, Lin YH, Min W, Qiao Y, Bonin C, Hargis G, Wang Y, Yang P, Kreutzer DL, Wang Y, Liu Y, Yu Y, Liu Y, Zhou D. J Clin Invest. 2024 May 7; 2024 May 7. PMID: 38713523.
• Renalase Levels are Decreased in Maternal Blood and Placental Tissues in Pregnancies Associated with Preterm Preeclampsia.Soliman Y, Eke C, Guo X, Wang M, Silva T, Désir GV, Konnikova L. Res Sq. 2024 May 6; 2024 May 6. PMID: 38765989.