Anita Huttner, MD
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Appointments
Pathology
Primary
Contact Info
About
Titles
Associate Professor of Pathology
Appointments
Pathology
Associate Professor on TermPrimary
Other Departments & Organizations
- Alzheimer's Disease Research Center (ADRC)
- Autopsy
- Brain Tumor Center
- Genomics, Genetics, and Epigenetics
- Neuropathology
- Pathology
- Pathology and Molecular Medicine
- Pathology Research
- Pituitary Program
- Program in Neurodevelopment and Regeneration
- Surgical Pathology
- Tissue Procurement & Distribution
- Tissue Services
- Yale Cancer Center
- Yale Medicine
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Clinical Fellow
- Yale Medical School - Yale New Haven Hospital (2016)
- Clinical Fellow
- Harvard Medical School - Brigham and Women's Hospital and Childrens' Hospital (2008)
- Resident
- Yale Medical School - Yale New Haven Hospital (2004)
- Resident
- Yale Medical School - Yale New Haven Hospital (2002)
- Pre-/Postdoctoral fellow
- National Institutes of Health (2000)
- MD
- University of Erlangen-Nurnberg (1998)
Research
Overview
Medical Subject Headings (MeSH)
Cells; Central Nervous System; Central Nervous System Diseases; Embryonic Structures; Hemic and Immune Systems; Musculoskeletal Diseases; Neoplasms; Nervous System; Nervous System Diseases; Neuroglia; Neurons; Pathological Conditions, Signs and Symptoms; Pluripotent Stem Cells; Synapses; Tissues
ORCID
0000-0003-2143-4329
Research at a Glance
Yale Co-Authors
Frequent collaborators of Anita Huttner's published research.
Publications Timeline
A big-picture view of Anita Huttner's research output by year.
Research Interests
Research topics Anita Huttner is interested in exploring.
Zeynep Erson Omay, PhD
Murat Gunel, MD, FACS, FAHA, FAANS
Robert Fulbright, MD
Joseph Piepmeier, MD, FAANS
Asher Marks, MD
Kanat Yalcin, MD
138Publications
7,295Citations
Neurons
Central Nervous System
Neoplasms
Nervous System Diseases
Neuroglia
Publications
2024
Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE)
Hanin A, Zhang L, Huttner A, Plu I, Mathon B, Bielle F, Navarro V, Hirsch L, Hafler D. Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE). Neurology Neuroimmunology & Neuroinflammation 2024, 11: e200259. PMID: 38810181, PMCID: PMC11139018, DOI: 10.1212/nxi.0000000000200259.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsNew-onset refractory status epilepticusTemporal lobe epilepsyGABAergic neuronsExcitatory neuronsInfiltrating macrophagesProportion of GABAergic neuronsChronic temporal lobe epilepsyRefractory status epilepticusInhibitory GABAergic neuronsSingle-cell transcriptome analysisDecreased expression of genesDegree of demyelinationImmune disturbancesNeuronal excitabilityImmune dysregulationNew-onsetStatus epilepticusPoor outcomeRefractory epilepsyHealthy childrenMicroglial reactivitySingle-nucleus RNA sequencingNLRP3 inflammasome activationInflammatory responseLobe epilepsy
2023
Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas
Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay E, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo I, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas. Scientific Reports 2023, 13: 22942. PMID: 38135704, PMCID: PMC10746716, DOI: 10.1038/s41598-023-48918-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInformatics platformDeep learning algorithmsImaging featuresCDKN2A alterationsLearning algorithmHeterozygous lossHomozygous deletionLarge datasetsDeep white matter invasionGBM molecular subtypesNew informaticsQualitative imaging biomarkersWhole-exome sequencingQualitative imaging featuresGBM resectionRadiographic evidenceWorse prognosisPACSMolecular subtypesPial invasionImaging biomarkersCDKN2A mutationsAllele statusNoninvasive identificationMagnetic resonance imagesChromosome instability and aneuploidy in the mammalian brain
Albert O, Sun S, Huttner A, Zhang Z, Suh Y, Campisi J, Vijg J, Montagna C. Chromosome instability and aneuploidy in the mammalian brain. Chromosome Research 2023, 31: 32. PMID: 37910282, PMCID: PMC10833588, DOI: 10.1007/s10577-023-09740-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChromosome instabilityExcess of chromosomesRole of aneuploidyNon-transformed cellsSomatic tissuesDiploid setChromosomal countsAneuploid cellsChromosomal alterationsMammalian brainCancer cellsAneuploidyCellsAging processChromosomesDevelopmental disordersPresent understandingSpecific consequencesDNAValuable insightsFuture research effortsBroad rangeHallmarkStructural modificationsIntrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma
Khang M, Lee J, Lee T, Suh H, Lee S, Cavaliere A, Rushing A, Geraldo L, Belitzky E, Rossano S, de Feyter H, Shin K, Huttner A, Roussel M, Thomas J, Carson R, Marquez-Nostra B, Bindra R, Saltzman W. Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma. Science Translational Medicine 2023, 15: eadi1617. PMID: 37910601, PMCID: PMC11078331, DOI: 10.1126/scitranslmed.adi1617.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluidDelivery of drugsEffective therapyTherapeutic indexPARP inhibitorsBlood-brain barrierSite of tumorRapid systemic clearanceXenograft mouse modelSolvent evaporation processAdministration of substancesLeptomeningeal spreadIntrathecal deliveryLeptomeningeal metastasesBrain penetrationSystemic clearanceTumor regressionPolymer nanoparticlesMetastatic medulloblastomaMouse modelPediatric medulloblastomaDrug accumulationCSF turnoverEncapsulated drugsPET imagingP13.02.A APPLICATION OF NOVEL PACS-BASED INFORMATICS PLATFORM TO IDENTIFY IMAGING BASED PREDICTORS OF CDKN2A ALLELIC STATUS IN GLIOBLASTOMAS
Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay Z, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo I, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. P13.02.A APPLICATION OF NOVEL PACS-BASED INFORMATICS PLATFORM TO IDENTIFY IMAGING BASED PREDICTORS OF CDKN2A ALLELIC STATUS IN GLIOBLASTOMAS. Neuro-Oncology 2023, 25: ii100-ii101. PMCID: PMC10489329, DOI: 10.1093/neuonc/noad137.336.Peer-Reviewed Original ResearchConceptsImaging featuresPial invasionQualitative imaging biomarkersQualitative imaging featuresWorse prognosisImaging biomarkersCDKN2A mutationsMethods Sixty-nine patientsCDKN2A alterationsHomozygous deletionHeterozygous lossSixty-nine patientsDeep white matterDeep white matter invasionGBM molecular subtypesWhole-exome sequencingNine patientsGBM resectionRadiographic evidenceMolecular subtypesBACKGROUND GliomasWhite matterAllele statusNoninvasive identificationGliomasP13.05.B INCORPORATION OF AI-BASED AUTOSEGMENTATION AND CLASSIFICATION INTO NEURORADIOLOGY WORKFLOW: PACS-BASED AI TO BUILD YALE GLIOMA DATASET
Tillmanns N, Lost J, Merkaj S, von Reppert M, Chadha S, Lin M, Bousabarah K, Huttner A, Aneja S, Avesta A, Omuro A, Aboian M. P13.05.B INCORPORATION OF AI-BASED AUTOSEGMENTATION AND CLASSIFICATION INTO NEURORADIOLOGY WORKFLOW: PACS-BASED AI TO BUILD YALE GLIOMA DATASET. Neuro-Oncology 2023, 25: ii101-ii101. PMCID: PMC10489908, DOI: 10.1093/neuonc/noad137.339.Peer-Reviewed Original ResearchNeuropathology of New-Onset Refractory Status Epilepticus (NORSE)
Hanin A, Cespedes J, Huttner A, Strelnikov D, Gopaul M, DiStasio M, Vezzani A, Hirsch L, Aronica E. Neuropathology of New-Onset Refractory Status Epilepticus (NORSE). Journal Of Neurology 2023, 270: 3688-3702. PMID: 37079033, DOI: 10.1007/s00415-023-11726-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNew-onset refractory status epilepticusCryptogenic new-onset refractory status epilepticusRefractory status epilepticusNeuropathology findingsStatus epilepticusSecondary neuronal injuryCryptogenic casesFebrile illnessNeuronal injuryExtensive workupNeuropathological evaluationEpilepsy surgeryPathophysiological mechanismsUnknown causePatient managementLong-term consequencesSevere formSpecific treatmentEpilepticusTissue samplesBiopsyPatientsFindings of studiesAutopsiesFindingsReview and standard operating procedures for collection of biospecimens and analysis of biomarkers in new onset refractory status epilepticus
Hanin A, Cespedes J, Pulluru Y, Gopaul M, Aronica E, Decampo D, Helbig I, Howe C, Huttner A, Koh S, Navarro V, Taraschenko O, Vezzani A, Wilson M, Xian J, Gaspard N, Hirsch L. Review and standard operating procedures for collection of biospecimens and analysis of biomarkers in new onset refractory status epilepticus. Epilepsia 2023, 64: 1444-1457. PMID: 37039049, PMCID: PMC10756682, DOI: 10.1111/epi.17600.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNew-onset refractory status epilepticusFebrile infection-related epilepsy syndromeRefractory status epilepticusStatus epilepticusCollection of biospecimensManagement of patientsStatus epilepticus patientsBetter clinical managementDisease-specific therapiesFebrile illnessStudy cohortEpilepsy syndromesOutcome endpointsStandard operating proceduresClinical managementRare conditionSevere formAnalysis of biomarkersPatientsMulticenter researchEpilepticusSpecific biomarkersExact causeSmall sample sizeBiospecimen collectionVascular steal and associated intratumoral aneurysms in highly vascular brain tumors: illustrative case
Hong C, Marianayagam N, Morales-Valero S, Barak T, Tabor J, O’Brien J, Huttner A, Baehring J, Gunel M, Erson-Omay E, Fulbright R, Matouk C, Moliterno J. Vascular steal and associated intratumoral aneurysms in highly vascular brain tumors: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22512. PMID: 36880509, PMCID: PMC10550659, DOI: 10.3171/case22512.Peer-Reviewed Original ResearchConceptsVascular brain tumorsVascular stealIntratumoral aneurysmBrain tumorsAdditional vascular imagingRight ophthalmic arteryMaximal safe resectionDiagnostic cerebral angiographyMinimal blood lossVascular steal phenomenonOpen tumor resectionDural-based lesionsSteal phenomenonBlood lossCerebral angiographyClinical suspicionNeurological symptomsOphthalmic arterySurgical strategySafe resectionVascular tumorsBlurred visionEndovascular embolizationTomography angiographyTumor resectionAnti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
Clinical Trials
Current Trials
SV2A PET Imaging in Healthy Subjects and Epilepsy Patients
HIC ID1603017469RoleSub InvestigatorPrimary Completion Date05/01/2024Recruiting ParticipantsGenderBothAge18 years - 90 years
Academic Achievements and Community Involvement
honor Averill A. Liebow Award for Excellence in the Teaching of Pathology Residents
Yale School of Medicine AwardYale University School of Medicine, Department of PathologyDetails06/30/2009United Stateshonor Nomination for the Alice Bohmfalk Teaching Award in Basic Science
Yale School of Medicine AwardYale University School of MedicineDetails05/01/2005United States
Clinical Care
Overview
Anita Huttner, MD, is a pathologist who specializes in identifying diseases and cancers in the brain. “By looking at tumor cells under a microscope, I can see how they behave, which helps to shed light on their behavior in the brain as soon as they become tumor cells,” Dr. Huttner says.
In addition to her specialty in neuropathology, Dr. Huttner has studied molecular diagnostic pathology. “This means I can incorporate the genetic sequencing results of a brain tumor into my visual analysis of the tumor cells,” she says.
For her research, Dr. Huttner uses stem cells to “recreate the brain’s disorder found in diseases like epilepsy and Alzheimer’s disease.” Even though this research is in the early stages of development, she hopes to find better treatments for brain tumors soon. Dr. Huttner explains that she feels compelled to investigate brain tumors because her father died from one. “I feel for my patients,” she says.
At Yale School of Medicine, Dr. Huttner is an associate professor of pathology.
Clinical Specialties
Pathology; Neuropathology; Molecular & Genomic Pathology
Board Certifications
Molecular Genetic Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2018
Neuropathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2015
Anatomic Pathology
- Certification Organization
- AB of Pathology
- Latest Certification Date
- 2023
- Original Certification Date
- 2012
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News
- December 18, 2022
Yale Insights in Cardiovascular Medicine: 2022
- October 04, 2022
Yale Study Substantiates Impact of Aducanumab in Reducing Plaque Associated With Alzheimer’s
- May 02, 2022
Yale Pathology Diagnostic Pathology CME Annual Review Scheduled for September 17-18 at Yale Club of NYC
- May 28, 2021
Recent Research Sheds Light on Link Between Meningiomas and Seizures
Get In Touch
Contacts
Locations
Department of Pathology
Academic Office
Brady Memorial Laboratory
310 Cedar Street, Ste LH108C
New Haven, CT 06510
Clinical Inquiry
203.737.5601Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.