New Advanced Diagnostic Tests Lab to Perform, Interpret Clinical-Grade Molecular Testing of Biomarkers
The Yale Advanced Diagnostic Tests Laboratory in the Department of Pathology, is a new unit of Yale Pathology Laboratories, offers access to novel molecular tests to external users, performing and interpreting clinical grade and high-quality molecular analysis of human tissue samples.
Yale scientists chosen by White House to expedite cancer research
Yale is one of three institutions that have been honored with the White House Cancer Moonshot research grant. Yale's Douglas Hanlon, PhD, research scientist in dermatology, and Richard Edelson, MD, the Anthony N. Brady Professor of Dermatology, describe their groundbreaking research, using mRNA technology to create a vaccine that targets only cancer cells.Source: WTNH News 8
Sang Taek Kim Returns to YSM to Lead Immunotherapy Adverse Events Program
A physician scientist, Sang Taek Kim, MD, PhD, assistant professor of medicine (rheumatology), is interested in the autoimmune complications induced by cancer immunotherapy. In his new role, he serves as director of the Immunotherapy Adverse Events in Rheumatology Program.
Discovering the 'Cytokine Language' That Activates Immune Responses
Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale team studied how individual immune cells react to combinations of cytokines, or small proteins released by cells that regulate inflammation. They discovered that certain cytokines have a synergistic effect, inducing unique gene activation programs compared to their individual effects. This cryptography of cytokine signals acts as a language, instructing immune cells.
Woman's Colleague Spots Mark on Her Arm That Led to Cancer Diagnosis
A rise in melanoma cases in recent years has led the American Cancer Society to estimate that approximately 97,610 new cases will be diagnosed in 2023, resulting in 7,990 deaths. Although the average age to receive a diagnosis is 65, melanoma can occur at any age and is prevalent in young females. Fortunately, there are ways to reduce the risk of melanoma or to catch it early. Dr. Jonathan Leventhal, the director of the Onco-Dermatology Program at Smilow Cancer Hospital and Yale Cancer Center said that UV exposure is the primary risk of skin cancer, so the importance of sun safety shouldn't be underestimated. "UV exposure is the greatest environmental risk factor, so prevention includes avoiding UV damage to the skin," Leventhal told Newsweek. "Avoid tanning beds, protect skin outdoors by seeking shade, wear protective clothing, hat, and sunglasses, apply broad-spectrum sunscreen SPF 30 or above, and reapply frequently.Source: Newsweek
Fierce 50 Breakthroughs
When the 2018 Nobel Prize in Physiology or Medicine recognized discoveries in cancer immune checkpoints, one name was notably missing from the winners: Lieping Chen, Ph.D., from Yale University. Chen’s lab at Mayo Clinic then first identified B7-H1, which was later renamed PD-L1. In 2002, Chen’s team was the first to report the PD-1/L1 axis as an immune evasion mechanism for cancer cells. “These findings have implications for the design of T cell-based cancer immunotherapy,” Chen and colleagues wrote presciently in their 2002 Nature Medicine article.Source: Fierce