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Less Restrictive Health Laws Linked to Higher HPV Vaccination Rates

November 15, 2021
by Mallory Locklear

The human papillomavirus (HPV) vaccine, which is recommended for children between ages 11 and 12, is highly effective at preventing cervical cancer. But in the United States, only 54% of adolescents are fully vaccinated against HPV, a rate lower than those of other adolescent vaccines, including those preventing meningitis, tetanus, diphtheria, and pertussis.

A new Yale study finds that an important strategy for improving vaccination rates could be allowing adolescents to consent for the HPV vaccine without parental involvement, which is already a policy in a handful of U.S. states.

For the study, published Nov. 15 in JAMA Pediatrics, researchers analyzed adolescent vaccination data in the United States from 2015 to 2018, comparing HPV vaccination rates between the jurisdictions with these laws and those without. The data set included 81,889 adolescents aged 13 to 17.

They found a positive correlation between the jurisdictions that allow adolescents to consent to the HPV vaccine and higher first-dose vaccination rates. In areas with the laws, 67.9% of adolescents had received at least the first dose of the vaccine compared with 61.4% of adolescents in states without the laws.

While the researchers can’t say definitely whether these laws are driving the higher vaccination rates, it’s worth considering what impact they might have if adopted more widely, said Sangini Sheth, associate professor of obstetrics, gynecology, and reproductive sciences at Yale and senior author of the study.

“It’s certainly food for thought,” she said. “I think it could lead to some very interesting policy conversations.”

Along with the HPV vaccine, the Centers for Disease Control and Prevention recommend that adolescents receive the Tdap vaccine — which protects against tetanus, diphtheria, and pertussis — and a meningitis vaccine that protects against four different strains of meningococcal bacteria. Immunization rates for both are higher than that of the HPV vaccine. Nearly 89% of adolescents are vaccinated against meningitis and over 90% are vaccinated with Tdap.

Sheth says that one reason HPV vaccination rates lag behind those of other adolescent vaccines is because the HPV vaccine is often not approached in the same way. “We know it’s safe, we know it’s highly effective, but I think it’s still treated differently,” said Sheth. “Whether parents think that the HPV vaccine is somewhat optional, that their children can wait and get it at some later point, or that it’s not for all children — none of that is true. And sometimes the HPV vaccine is not discussed at all.”

States and jurisdictions that have passed laws allowing adolescents to receive the vaccination without parental consent include Alabama, Alaska, California, Delaware, Idaho, New York, Oregon, South Carolina, and Washington, D.C. The laws fall into two main categories. Most allow adolescents to consent for care regarding sexual health and reproduction. And some allow adolescents to consent to care more broadly.

While the study found a positive correlation between the consent laws and higher rates of initiating the vaccine series, there was less association between these laws and completing the multidose vaccine series, which includes two or three doses depending on the age when individuals receive the first dose.

“It makes sense that the ability to consent seems to be more associated with starting the vaccine series,” said Sheth. “When it comes to that initial decision, an adolescent being able to make the decision for themselves might make a difference.”

As for how to encourage adolescents to complete the vaccine series, Sheth said systems for sending reminders to the adolescent or their family and to the clinician can help. “And I think what needs to be studied more is the effect of having a pro-vaccine culture within a practice, where everyone owns that vaccine messaging, from the waiting room and front desk staff to the nurses and clinicians.”

Other Yale authors include Nicholaus Johnson, Mallory Ellingson, Caitlin Hansen, Carlos Oliveira, and Linda Niccolai.

Submitted by Jess Collins on November 15, 2021