Christian Schlieker, PhD

Associate Professor Tenure

Research Interests

Biochemistry; Biophysics; Cell Biology; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Research Organizations

Molecular Biophysics and Biochemistry: Schlieker Lab

Cell Biology

Molecular Virology: Virology Laboratories

Yale Cancer Center: Virus and Other Infection-associated Cancers

Office of Cooperative Research

Research Summary

Mechanisms of membrane dynamics in relation to nuclear envelopathies and viral infection

Nuclear envelopathies are a diverse group of congenital diseases that are caused by mutations affecting proteins in the nuclear envelope or lamina. We hypothesize that envelopathy-associated alleles act at least in part through a gain of function mechanism that leads to a poisoning of nuclear membrane dynamics. Our goal is to unravel the cellular mechanisms that regulate protein homeostasis in the nuclear periphery, and to elucidate the role that these pathways play in muscular dystrophies, premature aging and related envelopathies. We exploit viral proteins known to manipulate the nuclear envelope as a novel approach to identify cellular factors involved in protein turnover and non-canonical nuclear transport via vesicular intermediates.

Specialized Terms: DYT1 Dystonia, Membrane dynamics; Torsin ATPases; Alternative nuclear transport (nuclear egress); Protein quality control; viral pathogenesis

Selected Publications

Full List of PubMed Publications

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