Advanced Cardiovascular Magnetic Resonance for Detection of Programmed Cell Death Protein-1 Deficient Myocarditis

We hypothesize that advanced CMR can detect myocardial structural, functional, and metabolic changes associated with autoimmune myocarditis in cardio-toxicity associated with CPI therapy of the PD-1 pathway in cancer patients. We propose to do this by applying advanced CMR methods for edema and fibrosis to detect early inflammation and cardio-toxicity in patients receiving CPI therapy.