Minimally invasive surgery effective for early-stage lung cancer
Survival rates among patients with stage I non-small cell lung cancer who underwent video-assisted thoracic surgery appeared similar to those of patients who underwent traditional thoracotomy, according to results of a retrospective cohort noninferiority study. “Our study suggests that the minimally invasive approach is just as effective as the traditional approaches through a bigger incision,” Daniel J. Boffa, MD, associate professor of thoracic surgery at Yale School of Medicine, told HemOnc Today. “Minimally invasive surgical techniques can be used in patients with early-stage lung cancer without compromising the potential for surgery to cure the patient.”Source: Healio
Five things everyone should know about breast cancer
In 2017, the American Cancer Society estimates more than 250,000 new cases of breast cancer will be diagnosed in the United States, with more than 40,000 deaths. But progress in treatment and early detection has led to improved survival rates, with more than 3 million breast cancer survivors in the U.S. today. With October marking National Breast Cancer Awareness Month, Anees Chagpar, M.D., M.P.H., a breast cancer expert and assistant director for Global Oncology at Yale Cancer Center, sorts out the facts about breast cancer and offers simple ways to reduce risk.
With Breast Cancer, the Best Treatment May be No Treatment
MAMMOGRAPHY, THE BOOB-SMOOSHING imaging technique used to detect breast cancer, has an overdiagnosis problem. Doctors have long known that some portion of the tumors revealed by the scans might never become life-threatening—but they haven’t been able to discern harmless growths from those that grow and spread. Finally, though, researchers have learned which cancers account for the majority of problematic diagnoses—and their work suggests mammograms are better at catching innocuous tumors than deadly ones. In a paper published Wednesday in The New England Journal of Medicine, Yale University scientists analyzed invasive tumor data from hundreds of thousands of breast cancer patients nationwide. The researchers divided the tumors according biological features—how closely they resembled normal breast cells and whether they had certain hormone receptors. Turns out those features could predict whether a small tumor would grow into a big one.Source: Wired
Tanning Dependence Linked to Other Addictive Behaviors, New Study Finds
Despite the known dangers of exposure to ultraviolet light, many people continue to sunbathe and use indoor tanning beds with some users exhibiting a dependence to tanning. A new study from the Yale School of Public Health finds that such dependence is also associated with other addictive behaviors.
Innovative breast reconstruction: An amazing result enhances self-esteem
For Lauren Raccio, breast cancer treatment at Yale Medicine started because her life was in danger. The journey involved a remarkable form of breast reconstruction called ‘DIEP flap.’ The result is a breast that looks and feels natural, and is more resilient to radiation after surgery.Source: Yale Medicine
2016's Top 5 Advances in Oncology Immunotherapy, in one form or another, dominated the specialty
MedPage Today asked specialists in oncology around the country to tell us what they thought were the most important clinical developments in 2016. More than half of the oncologists who responded to our request cited one or more developments in immunotherapy/immuno-oncology. The story will continue to unfold in the coming year. "This year, we saw several studies showing dramatic results for immunotherapy in heavily pretreated breast cancer patients with advanced triple-negative breast cancer," said Anees Chagpar, MD, of Yale Cancer Center in New Haven, Conn. "This has led to new clinical trials to evaluate immune checkpoint inhibitors in patients with earlier-stage disease -- stay tuned!"Source: MedPage Today
Researchers Identify Heterogeneity of Tissue Resident Memory T Cells as Targets of Checkpoint Therapies
Researchers at Yale Cancer Center and Yale Medicine have identified the critical target of new immune-checkpoint therapies: subsets of immune cells called tissue resident memory (TRM) T cells. In the same research, scientists also found that individual metastatic cancer lesions contain unique sets of TRM cells.
Dr. Anees B. Chagpar on the Hottest Topics in Breast Cancer Management
Anees B. Chagpar, MD, associate professor of Surgery (Oncology), director of The Breast Center at Smilow Cancer Hospital at Yale-New Haven, Yale Cancer Center, explains some of the most discussed topics in breast cancer.Source: OncLive
Dr. Brigid Killelea on Nipple-Sparing Mastectomy for Breast Cancer
Brigid Killelea, MD, MPH, FACS, associate professor of surgery (oncology), Yale Cancer Center, discusses the potential of nipple-sparing mastectomy for women who undergo surgery for breast cancer. The data around nipple-sparing mastectomy, also referred to as total skin-sparing mastectomy, are very exciting, says Killelea. This is a more challenging operation, but it really gives a superior outcome in terms of cosmesis, she says. Most of the recent studies have been very encouraging, and have not shown any increase in the risk of recurrence for patients that undergo nipple-sparing mastectomy, if they are selected properly.Source: OncLive
Why negative results are worthy of publication
Researchers don’t dream of negative results, but experiments and trials that don’t go as expected are crucial for moving science forward. To highlight this important part of the research process, we asked research scientists to speak about their own experiences with “failure.” Anees Chagpar is an Associate Professor of Surgery at Yale University and Director of the Breast Center at Smilow Cancer Hospital. She explains why she considers her non-significant and negative studies to be important parts of her publication history.Source: Research Gate
Yale Cancer Center Researchers Identify New T cell Subsets with Potential to Improve Cellular Therapy for Cancer
A Yale Cancer Center research team has identified that two genes, NR4A1 and ABC transporters, mark a distinct subset of quiescent T cells within human tissues, and have developed methods to mobilize them into circulation for potential application in adoptive T cell therapy of cancer.
Two months after cancer surgery, Baker's Gonsioroski ready for football
Knowing the gravity and complexity of Luke’s surgery, Dr. Alexander Kraev of the Billings Clinic made a recommendation to the family to have Dr. Frank Detterback, the Chief of Thoracic Surgery at Yale University and Associated Director of the Yale Cancer Center in New Haven, Conn., do the procedure. “The Lord gave us the best guy in the world,” said Katina. “Kraev was his understudy. He recommended us to his mentor.” Luke and his family left for Yale on June 8.Source: Billings Gazzette
Scientists rehash evidence on sunscreen and skin cancer
There isn't much evidence to conclusively prove that daily sunscreen use can prevent most skin cancers, a research review concludes. But that doesn't mean we shouldn't use sunscreen, doctors say. It just means it's unethical to do experiments testing the effectiveness of sunscreen by randomly assigning some people to use it and others to skip it.Source: Fox News