Multiple Myeloma, Phase III
A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Ciltacabtagene Autoleucel, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy
Volunteers
Health Professionals
What is the purpose of this trial?
The purpose of this study is to compare the efficacy of Bortezomib, Lenalidomide and Dexamethasone (VRd) induction followed by a single administration of ciltacabtagene autoleucel (cilta-cel) versus VRd induction followed by Lenalidomide and Dexamethasone (Rd) maintenance in newly diagnosed multiple myeloma participants for whom ASCT is not planned as initial therapy in terms of Progression Free Survival (PFS).
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Principal Investigator
Sub-Investigators
- Adam Boruchov, MD
- Agatha Hecht
- Alessia Donadio, MD
- Alexis Walker
- Alfredo Axtmayer
- Alison Johnson
- Amer Zeidan, MBBS
- Amy Pugliese
- Ashita Talsania, MRCP, MBBS
- Beverly Drucker, MD, PhD
- Brooke Chaves
- Carolyn Demsky, APRN
- Catherine Wei, MD
- D. Barry Boyd, MD, MS
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Elizabeth Cappiello
- Emily Collier, MD
- Erica Stevens
- Francesca Montanari, MD
- Francine Foss, MD
- Harold Tara Jr, MD
- Iris Isufi, MD
- Jade Vanacore
- James Vredenburgh, MD
- Jose Morales-Marin
- Karishma Mehra, MBBS
- Katherine Harvey, MD, MPH
- Kathleen Fenn, MD
- Kerri Ann Rall
- Larisa Fleysher
- Laura Sabourin
- Leena Rahmat
- M. Sung Lee, MD
- Madeline Santiago
- Manoj M Pillai, MBBS
- Maureen McGlennon
- Meifeng Shen
- Michael Cohenuram, MD
- Michael Grant, MD
- Michael Hurwitz, MD, PhD
- Natalia Neparidze, MD
- Neal Fischbach, MD
- Pawan Karanam, MD
- Renee Moye
- Sabrina Browning, MD
- Sarah Carlson
- Sarah Thomen, APRN
- Sharynn Hall, MD, PhD
- Stephanie Halene, MD, Dr Med
- Stephanie Kacik
- Stuart Seropian, MD
- Su Hsien Lim, MD
- Sudhanshu Mulay, MD
- Syed Ali
- Syed Bilgrami, MBBS
- Tara Anderson
- Terri Parker, MD
- Victor Chang, MD
- Vidya Kesavan
- Wajih Kidwai, MD, FACP
- Xuanthao Thi Nguyen
- Zia Rahman, MD
- Last Updated04/16/2024
- Study HIC#2000032283