Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving a shorter hormone therapy treatment may work the same at controlling prostate cancer compared to the usual 24 month hormone therapy treatment in patients with low gene risk score. Adding apalutamide to the usual treatment may increase the length of time without prostate cancer spreading as compared to the usual treatment in patients with high gene risk score.
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Principal Investigator
Sub-Investigators
- Abhijit Patel, MD, PhD
- Allison Campbell, MD, PhD
- Anca Bulgaru, MD
- Anne Chiang, MD, PhD
- Armand Russo, MD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Bruce A. McGibbon, MD
- Carrie Fijal, MSN, AGPCNP-BC, OCN
- Catherine Wei, MD
- Christin A. Knowlton, MD, MA
- D. Barry Boyd, MD, MS
- Daniel P. Petrylak, MD
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Emily Duffield, APRN
- Emily Kopas, APRN, OCN
- Francesca Montanari, MD
- Gabrielle W. Peters, MD
- Gloria Huang, MD, FACOG
- Harold Tara Jr, MD
- James E. Hansen, MD, MS
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- Joseph Kim, MD
- Jung Yun Julie Kang, MD, PhD
- Justin Persico, MD
- Kathleen Fenn, MD
- Kayla Martello
- Kelsey Martin, MD
- Kenneth B. Roberts, MD
- Kevin Du, MD, PhD, MSCI
- Kimberly L. Johung, MD, PhD
- Kristen Hoxie
- Larisa Fleysher
- M. Sung Lee, MD
- Marianne Davies, NP, DNP, MSN, BSN
- Matthew Austin, MD
- Meena S. Moran, MD
- Melissa Rasar Young, MD, PhD
- Michael Cohenuram, MD
- Michael Hurwitz, MD, PhD
- Nadine Housri, MD
- Neal Fischbach, MD
- Osarugue Otasowie
- Rebecca Vanasse-Passas, MD
- Renee Moye
- Robert Legare, MD
- Sanjay Aneja, MD
- Sara Anastasio, RN
- Sarah Carlson
- Sarah Goldberg, MD, MPH
- Shari Damast, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Susan A. Higgins, MD
- Thomas Hayman, MD, PhD
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Last Updated03/05/2024
- Study HIC#2000032279